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Your search keyword '"Xia, Xianzhu"' showing total 6 results
Start Over Author "Xia, Xianzhu" Journal international immunopharmacology
6 results on '"Xia, Xianzhu"'

2. Equine immunoglobulin F(ab′)2 fragments protect mice from Rift Valley fever virus infection

Author

Zhao, Yongkun, primary, Zheng, Xuexing, additional, He, Shihua, additional, Li, Yuetao, additional, Wang, Wei, additional, Gai, Weiwei, additional, Wong, Gary, additional, Wang, Hualei, additional, Yan, Feihu, additional, Xue, Feng, additional, Feng, Na, additional, Wang, Tiecheng, additional, Gao, Yuwei, additional, Yang, Songtao, additional, Qiu, Xiangguo, additional, and Xia, Xianzhu, additional

Published
2018
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3. Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses

Author

Liu, Jing, primary, Ren, Zhiguang, additional, Wang, Hongmei, additional, Zhao, Yongkun, additional, Wilker, Peter R., additional, Yu, Zhijun, additional, Sun, Weiyang, additional, Wang, Tiecheng, additional, Feng, Na, additional, Li, Yuanguo, additional, Wang, Hualei, additional, Ji, Xianliang, additional, Li, Nan, additional, Yang, Songtao, additional, He, Hongbin, additional, Qin, Chuan, additional, Gao, Yuwei, additional, and Xia, Xianzhu, additional

Published
2018
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4. Intramuscular and intranasal immunization with an H7N9 influenza virus-like particle vaccine protects mice against lethal influenza virus challenge

Author

Ren, Zhiguang, primary, Zhao, Yongkun, additional, Liu, Jing, additional, Ji, Xianliang, additional, Meng, Lingnan, additional, Wang, Tiecheng, additional, Sun, Weiyang, additional, Zhang, Kun, additional, Sang, Xiaoyu, additional, Yu, Zhijun, additional, Li, Yuanguo, additional, Feng, Na, additional, Wang, Hualei, additional, Yang, Songtao, additional, Yang, Zhengyan, additional, Ma, Yuanfang, additional, Gao, Yuwei, additional, and Xia, Xianzhu, additional

Published
2018
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6. Equine immunoglobulin F(ab') 2 fragments protect mice from Rift Valley fever virus infection.

Author

Zhao Y, Zheng X, He S, Li Y, Wang W, Gai W, Wong G, Wang H, Yan F, Xue F, Feng N, Wang T, Gao Y, Yang S, Qiu X, and Xia X

Subjects
Animals, Antibodies, Viral blood, Cells, Cultured, Female, Horses, Immunoglobulin G blood, Male, Mice, Mice, Inbred BALB C, Rift Valley fever virus immunology, Rift Valley fever virus isolation & purification, Virion isolation & purification, Immunization, Passive, Immunoglobulin Fab Fragments immunology, Rift Valley Fever prevention & control
Abstract

Background: Rift Valley fever virus (RVFV) is an emerging arbovirus in Africa and the Arabian Peninsula, in which infection with RVFV poses a serious threat to humans and livestock globally. Approved treatments for RVFV infection, especially for use in humans, have not yet been developed. There is an urgent need for effective drugs to prevent RVFV disease., Methods: In previous study, we developed RVFV virus like particles (VLPs) expressing the surface glycoproteins Gn and Gc. The morphology was shown to be similar to live RVFV under electron microscopy. In this study, we immunized horses with RVFV VLPs, prepared the immunoglobulin F(ab') 2 fragments, and characterized its in vitro neutralization and in vivo efficacy in mice., Results: F(ab') 2 was found to potently neutralize RVFV in VeroE6 cells, and passive transfer of immunoglobulin F(ab') 2 fragments resulting in reduced mortality in RVFV infected mice., Conclusion: Our results show that passive immunotherapy with equine immunoglobulin F(ab') 2 fragments is a promising strategy to treat RVFV infections., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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