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Your search keyword '"Takashi Yahata"' showing total 4 results
Start Over Author "Takashi Yahata" Journal international immunology
4 results on '"Takashi Yahata"'

1. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

Author

Kazuyoshi Takeda, Masaru Taniguchi, Marimo Sato, Hidemitsu Kitamura, Masashi Sekimoto, Kenji Iwakabe, Takashi Nishimura, Ko Okumura, Luc Van Kaer, Akio Ohta, Minoru Nakui, Takashi Yahata, Tetsu Kawano, and Toshiaki Koda

Subjects
Antigens, Differentiation, T-Lymphocyte, CD40 Ligand, Immunology, Antigen presentation, Galactosylceramides, chemical and pharmacologic phenomena, Antigens, CD1, Interferon-gamma, Mice, Adjuvants, Immunologic, Antigens, CD, Animals, Immunology and Allergy, Cytotoxic T cell, Lectins, C-Type, CD40 Antigens, Antigen-presenting cell, Antigen Presentation, Membrane Glycoproteins, CD40, biology, Chemistry, Cell Differentiation, hemic and immune systems, Dendritic Cells, General Medicine, Dendritic cell, Natural killer T cell, Acquired immune system, Cell biology, Killer Cells, Natural, Mice, Inbred C57BL, carbohydrates (lipids), CD1D, biology.protein, lipids (amino acids, peptides, and proteins), Antigens, CD1d, T-Lymphocytes, Cytotoxic
Abstract

In vivo administration of NKT cell ligand, alpha-galactosylceramide (alpha-GalCer), caused the activation of NKT cells to induce a strong NK activity and cytokine production by CD1d-restricted mechanisms. Surprisingly, we also found that alpha-GalCer induced the activation of immunoregulatory cells involved in acquired immunity. Specifically, in vivo administration of alpha-GalCer resulted in the induction of the early activation marker CD69 on CD4(+) T cells, CD8(+) T cells and B cells in addition to macrophages and NKT cells. However, no significant induction of CD69 was observed on cells from CD1d- or V(alpha)14 NKT-deficient mice, indicating an essential role for the interaction between NKT cells and CD1d-expressing dendritic cells (DC) in the activation of acquired immunity in response to alpha-GalCer. Indeed, in vivo injection of alpha-GalCer resulted not only in the activation of NKT cells but also in the generation of CD69(+)CD8(+) T cells possessing both cytotoxic T lymphocyte (CTL) activity and IFN-gamma-producing ability. Tumor-specific CTL generation was also accelerated by alpha-GalCer. The critical role of CD40-CD40 ligand (CD40L)-mediated NKT-DC interaction during the development of CD69(+)CD8(+) CTL by alpha-GalCer was demonstrated by blocking experiments using anti-CD40L mAb. These findings provide direct evidence for a critical role of CD1d-restricted NKT cells and DC in bridging innate and acquired immunity.

Published
2000

2. A pivotal role of IL-12 in Th1-dependent mouse liver injury

Author

Sonoko Habu, Takashi Yahata, Akiko Takahashi, Yoshitaka Tanaka, Kazuhito Watanabe, Kiyoshi Takayama, and Takashi Nishimura

Subjects
Lipopolysaccharides, Cellular immunity, Lipopolysaccharide, medicine.medical_treatment, Immunology, Molecular Sequence Data, Mice, Nude, Polymerase Chain Reaction, Propionibacterium acnes, chemistry.chemical_compound, Interferon-gamma, Mice, In vivo, medicine, Immunology and Allergy, Animals, Interferon gamma, Liver injury, Immunity, Cellular, Mice, Inbred BALB C, Mice, Inbred ICR, biology, Base Sequence, business.industry, Liver Diseases, General Medicine, T-Lymphocytes, Helper-Inducer, biology.organism_classification, medicine.disease, Molecular biology, Interleukin-12, Mice, Inbred C57BL, Cytokine, chemistry, Liver, Interleukin 12, Disease Susceptibility, Chemical and Drug Induced Liver Injury, business, medicine.drug
Abstract

Intravenous injection of Propionibacterium acnes and lipopolysaccharide (LPS) with a 7 day interval caused CD4+ T cell-dependent severe liver injury in the C57BL/6 (H-2b) mouse strain. In contrast, BALB/c (H-2d) mice were resistant to P. acnes and LPS-induced liver injury. The different susceptibilities of the two mouse strains to liver injury appeared to be closely correlated with their different abilities to produce IFN-gamma after P. acnes priming. Namely, the sensitive C57BL/6 mouse strain produced a significant level of IFN-gamma 7-10 days after P. acnes injection, whereas no significant amount of serum IFN-gamma was detected in the resistant BALB/c mouse strain. The important role of IFN-gamma in liver injury was demonstrated from the finding that in vivo administration of anti-IFN-gamma mAb abrogated P. acnes and LPS-induced liver injury in C57BL/6 mice. Moreover, it was demonstrated that in vivo administration of recombinant IL-12, a key cytokine for the induction of IFN-gamma, into mice induced P. acnes and LPS-induced liver injury in the resistant BALB/c mouse strain. Conversely, in vivo administration of anti-IL-12 mAb blocked the development of liver injury in the sensitive C57BL/6 mouse strain. Moreover, it was demonstrated that the failure of the induction of liver injury in BALB/c mice appeared to be derived from the lack of expression of IL-12 at the local site of liver in P. acnes-primed mice. These results strongly indicated that endogenous IL-12, which stimulates Th1-dominant cellular immunity and IFN-gamma production, may be an essential cytokine on the course of T cell-dependent liver injury.

Published
1996

3. Common marmoset CD117+ hematopoietic cells possess multipotency.

Author

Shin Shimada, Satoshi Nunomura, Shuya Mori, Hiroshi Suemizu, Toshio Itoh, Shuji Takabayashi, Yoshinori Okada, Takashi Yahata, Takashi Shiina, Hideki Katoh, Ryuji Suzuki, Kenzaburo Tani, Kiyoshi Ando, Hideo Yagita, Sonoko Habu, Erika Sasaki, and Yoshie Kametani

Subjects
CALLITHRIX jacchus, HEMATOPOIETIC stem cells, STEM cell factor, PROGENITOR cells, IMMUNITY, LABORATORY mice
Abstract

Analysis of the hematopoiesis of non-human primates is important to clarify the evolution of primate-specific hematopoiesis and immune regulation. However, the engraftment and development of the primate hematopoietic system are well-documented only in humans and are not clear in non-human primates. Callithrix jacchus (common marmoset, CM) is a New World monkey with a high rate of pregnancy and small size that lives in closed colonies. As stem cell factor (SCF) is an essential molecule for hematopoietic stem cell development in mice and humans, we focused on CD117, the SCF receptor, and examined whether CD117-expressing cells possess the hematopoietic stem/progenitor cell characteristics of newborn marmoset-derived hematopoietic cells that can develop into T cells and B cells. When CD117+ cell fractions of the bone marrow were transplanted into immunodeficient NOD (non-obese diabetic)/Shi-scid, common γc-null (NOG) mice, these cells engrafted efficiently in the bone marrow and spleens of the NOG mice. The CD117+ cells developed into myeloid lineage cells, CD20+ B cells and CD3+ T cells, which could express CM cytokines in vivo. The development of B cells did not precede that of T cells. The development of CD8+ T cells was dominant in NOG mice. The engraftment was comparable for both CD117+CD34+ cells and CD117+CD34- cells. These results suggest that the CD117+ cell fraction can differentiate into all three cell lineages, and the development of marmoset immunity in the xenogeneic environment follows diverse developmental pathways compared with human immunity. [ABSTRACT FROM AUTHOR]

Published
2015
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4. A pivotal role of IL-12 in Th1-dependent mouse liver injury.

Author

Yoshitaka Tanaka, Akiko Takahashi, Kazuhito Watanabe, Kiyoshi Takayama, Takashi Yahata, Sonoko Habu, and Takashi Nishimura

Abstract

Intravenous injection of Propionibacterium acnes and llpopolysaccharide (LPS) with a 7 day Interval caused CD4+ T cell-dependent severe liver injury in the C57BL/6 (H-2b) mouse strain. In contrast, BALB/c (H-2d) mice were resistant to P. acnes and LPS-lnduced liver Injury. The different susceptibilities of the two mouse strains to liver injury appeared to be closely correlated with their different abilities to produce IFN-γ after P. acnes priming. Namely, the sensitive C57BL/6 mouse strain produced a significant level of IFN-γ7-10 days after P. acnes injection, whereas no significant amount of serum IFN-γ was detected In the resistant BALB/c mouse strain. The important role of IFN-γ in liver injury was demonstrated from the finding that In vivo administration of anti-IFN-γ mAb abrogated P. acnes and LPS-induced liver Injury in C57BL/6 mice. Moreover, it was demonstrated that In vivo administration of recombinant IL-12, a key cytokine for the induction of IFN-γ, into mice induced P. acnes and LPS-induced liver Injury in the resistant BALB/c mouse strain. Conversely, In vivo administration of anti-IL-12 mAb blocked the development of liver injury In the sensitive C57BL/6 mouse strain. Moreover, It was demonstrated that the failure of the induction of liver injury in BALB/c mice appeared to be derived from the lack of expression of IL-12 at the local site of liver in P. acnes-prlmed mice. These results strongly indicated that endogenous IL-12, which stimulates Th1-dominant cellular immunity and IFN-γ production, may be an essential cytokine on the course of T cell-dependent liver injury. [ABSTRACT FROM AUTHOR]

Published
1996
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