1. Early statin therapy within 48 hours decreased one-year major adverse cardiac events in patients with acute myocardial infarction
- Author
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Myung Ho Jeong, Young Joon Hong, Hyung Wook Park, Min Chul Kim, Keun Ho Park, Jum Suk Ko, Kyung Hun Cho, Min Goo Lee, Jung Chaee Kang, Youngkeun Ahn, Jeong Gwan Cho, Nam Sik Yoon, Jong Chun Park, Kye Hun Kim, Doo Sun Sim, Hyun Ju Yoon, and Ju Han Kim
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,Statin ,Multivariate analysis ,Time Factors ,medicine.drug_class ,Group ii ,Myocardial Infarction ,Sensitivity and Specificity ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,In patient ,cardiovascular diseases ,Myocardial infarction ,Hospital Mortality ,Acute Coronary Syndrome ,Angioplasty, Balloon, Coronary ,Aged ,Retrospective Studies ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Treatment Outcome ,Cardiology ,Female ,Statin therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Mace ,Follow-Up Studies - Abstract
HMG-CoA reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome. We investigated whether early statin therapy would be effective at reducing MACE in patients with acute myocardial infarction (AMI).A total of 1,159 patients were analyzed. They were grouped by initiation time of statin administration after admission as follows: group I; n = 945, ≤ 48 hours, group II; n = 214, > 48 hours.Cardiovascular risk factors and noncardiac comorbidities were not different between the two groups. ST-elevation MI as initial diagnosis was more prevalent in group I (68.4% versus 59.3%, P = 0.013). In-hospital mortality was not different in the two groups (0.8% versus 0.5%, P = 0.483). In one-year clinical follow-up, MACE and repercutaneous coronary intervention were lower in group I (17.8% versus 24.6%, P = 0.016, 10.2% versus 15.5%, P = 0.021, respectively). However, there was no difference in mortality (3.8% versus 4.7%, P = 0.319). In multivariate analysis, statin initiation within 48 hours after admission was an independent predictor of one-year MACE (OR 1.49, 95% CI = 1.00-2.21, P = 0.045).Consequently, early statin therapy within 48 hours after admission reduced MACE at one-year follow-up in patients with AMI.
- Published
- 2011