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The Tibetan Plateau is a product of the continental collision between the Indian and Asian plates along the Indus-Yarlung suture zone that started in the early Cenozoic. This collision initially produced stress at the collisional boundary and later propagated with time on both the Indian plate and Asian plate. Many studies have reported tectonic deformation in the Himalayas representing the immediate response of continental collision on the Indian side near the collisional boundary. However, there have been only few studies on the early Cenozoic shortening structures in the Lhasa block that forms the southernmost part of the Asian plate. In this study, we performed Ar/Ar geochronology of syntectonic muscovite from the Sinongduo thrust system in the central Lhasa block. The results show that the Sinongduo thrust system was active in the Early Eocene. We interpret the Sinongduo thrust system as an immediate response to the India-Asia collision in the Lhasa block. This study reconciles the early Cenozoic India-Asia collision with the lack of tectonic response in the Lhasa block. [ABSTRACT FROM AUTHOR]