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Introduction: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. This study was designed to assess the clinical and biochemical parameters of dengue fever patients. Materials and methods: Prospective observational study was undertaken among adult patients in a Civil Hospital, Ahmedabad. Fifty patients were studied and analyzed. All patients who were NS1 antigen/IgM dengue positive were included in the study. Clinical features, hematological and biochemical parameters were noted. Results: Of the 50 patients studied, majority were males (64%). Fever was the major symptom (100%) followed by headache (96%), myalgia (94%), retro-orbital pain (64%), conjunctival injection (24%), rash (38%), abdominal pain (74%), pleural effusion (30%) and ascites (26%). Significant derangements in platelet (70%), leucocyte counts (78%) and serum transaminases (74%) were noted. Mortality rate was zero. Conclusion: Fever associated with headache, retro-orbital pain, erythematous morbilliform rash, conjunctival suffusion and itching in palms and soles along with thrombocytopenia, leucopenia, elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have little role in management of dengue patients. [ABSTRACT FROM AUTHOR]

Background: Malaria a tropical disease has a wide clinical spectrum ranging from uncomplicated disease to a fatal one. The objectives were to study clinical profile of Malaria with special reference to its complications and outcome. Materials and methods: A study was carried out in a tertiary care hospital including total of 50 patients diagnosed with P. Vivax or P. Falciparum Malaria. Data on patients' clinical details with investigations, complications, and outcome was studied. Results: Out of 50 patients (37 male and 13 female), 41 had P. Vivax and 9 had P. Falciparum Malaria. Total 3 patients were complicated; two had cerebral malaria due to P.falciparum and one had multi organ failure due to P. vivax which eventually succumbed. Conclusions: Clinical profile of Malaria was studied which suggest, P.falciparum malaria was more complicated; which comprises cerebral complications, renal complication, hepato-biliary and respiratory complications leading to increased morbidity and mortality. It was observed that P. vivax had better outcome but it can also present with serious and life-threatening complication. [ABSTRACT FROM AUTHOR]

Background: WHO announced influenza A H1N1 as pandemic (commonly known as swine flu) in 2009; but every year there is increase in influenza A H1N1 positive cases causing epidemics of febrile respiratory illness due to genetic re-assortment in influenza virus. This study aimed for clinical profile of patient with influenza A H1N1 and its outcome admitted at civil hospital Ahmedabad. Materials and methods: Present study was included 50 patients with influenza A H1N1; admitted in B.J. Medical College and Civil Hospital, Ahmedabad. This study was carried out for one year from June 2018 to June 2019. Patients were studied and managed as per standard Government of India protocol. Results: Total 50[19 (38%) males and 31 (62%) females] patients were studied for clinical spectrum, complications and outcome. All patients had fever (100%), dry cough in 92% of patients, throat pain in 88% of patients, breathlessness in 54% of patients, headache in 48% of patients, sputum production in 40% of patients and hemoptysis in 6% of patients. 35 (70%) patients had comorbidity. Total13 (26%) patients were complicated; out of which 4 (8%) patients required ventilatory support. Conclusion: Early case detection, categorizations according to symptoms prevention of treatment has better outcome and decreases disease related morbidity and mortality and burden of disease in community and voluntary early reporting should be encouraged through various health campaigns. [ABSTRACT FROM AUTHOR]

Background: In developing countries, the widespread use of organophosphorus compounds (OPCs) has been accompanied by increasing incidence of poisoning with these agents, both suicidal and accidental. This is attributed mainly to their easy availability, indiscriminate handling, storage and lack of knowledge about the serious consequences of poisoning. Of the various substance used for suicidal attempts in India, OPCs form a significant group. Since the clinical manifestation of OPC poisoning is diverse ranging from mild symptoms to fatal complications in the course of time, we need proper management of the situation. Materials and methods: Present study included 42 patients with Organophosphorus poisoning admitted in B.J. Medical College, and Civil Hospital Ahmedabad. This study was carried out from June 2018 to June 2019. Patients were managed as per standard protocols of O P poisoning. We also checked for various parameters on like cholinesterase level, complete blood counts, renal function test with electrolytes, liver function test. Results: In this study, majority of patients fell in 20-30 years of age group with male predominance. Most common clinical features were vomiting, miosis and giddiness. Majority of the patients belonged to mild grade. The average s.cholinesterase level was low as severity increases. More doses of PAM and atropine were required in severe poisoning. Most common complication was respiratory paralysis. Death was more in severe poisoning. Conclusion: OPC is one of the most common poisoning in India. In patients of OP poisoning presenting symptoms and s.ChE level directly correlated with severity. Therapeutic required dose of PAM and atropine are different in different grade of severity. Survival amongst patients is definitely better if atropine and PAM are being given with Mechanical ventilator support in cases of respiratory insufficiency. [ABSTRACT FROM AUTHOR]