1. A Multifunctional Cytokine (IL-6/BSF-2) and Its Receptor
- Author
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Toshio Hirano, Tetsuya Taga, Katsuhiko Yamasaki, Tadashi Matsuda, Bo Tang, Atsushi Muraguchi, Yasuhiro Horii, Sachiko Suematsu, Yuuichi Hirata, Hideo Yawata, Masatoshi Shimizu, Michiaki Kawano, and Tadamitsu Kishimoto
- Subjects
T-Lymphocytes ,medicine.medical_treatment ,Immunology ,Autoimmune Diseases ,Mice ,Immune system ,medicine ,Animals ,Humans ,Immunology and Allergy ,Receptors, Immunologic ,Growth Substances ,Interleukin 6 ,Receptor ,B cell ,biology ,Interleukin-6 ,Interleukins ,Macrophages ,Pokeweed mitogen ,General Medicine ,Receptors, Interleukin-6 ,Cytokine ,medicine.anatomical_structure ,Multigene Family ,Antibody Formation ,Interleukin-6 receptor ,biology.protein ,Immunoglobulin superfamily ,Plasmacytoma - Abstract
Interleukin 6 (IL-6)/B cell stimulatory factor 2 is a multifunctional cytokine produced by both lymphoid and nonlymphoid cells. IL-6 regulates immune response, acute phase reaction, and hematopoiesis. It was found that IL-6 production by T cells is dependent on macrophages, and IL-6 is one of essential factors for pokeweed mitogen induced immunoglobulin production. Both high- and low-affinity IL-6 receptors were identified. The molecular cloning of IL-6 receptors demonstrated that this receptor is a member of the immunoglobulin superfamily. The deregulated production of IL-6 is suggested to be involved in the pathogenesis of autoimmune diseases and in the development of multiple myeloma.
- Published
- 1989
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