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17 results on '"Masayuki Ando"'

1. Difference in Apoptotic Function between Eosinophils from Peripheral Blood and Bronchoalveolar Lavage in Chronic Eosinophilic Pneumonia

Author

Masayuki Ando, Naoki Saita, Hirotsugu Kohrogi, Mitsuomi Hirashima, and Tohru Yamanaka

Subjects
T cell, Immunology, Apoptosis, Granulocyte, Pathogenesis, medicine, Eosinophilic pneumonia, Humans, Immunology and Allergy, Pulmonary Eosinophilia, medicine.diagnostic_test, business.industry, Respiratory disease, General Medicine, respiratory system, Eosinophil, Flow Cytometry, medicine.disease, respiratory tract diseases, Eosinophils, Bronchoalveolar lavage, medicine.anatomical_structure, business, Bronchoalveolar Lavage Fluid
Abstract

We compared apoptosis in eosinophils from bronchoalveolar lavage (BAL-Eos) with that in eosinophils from peripheral blood (PB-Eos) of 4 patients with chronic eosinophilic pneumonia (CEP). The survival rate of the BAL-Eos on the 3rd day of the culture was significantly higher than that of the PB-Eos (39.1 vs. 1.3%). The percentage of apoptotic cells in the PB-Eos after a 24-hour incubation was higher than that in the BAL-Eos (21.7 vs. 10.6%) according to an analysis with annexin V. We further found that ECF-PI9, an eosinophil chemotactic factor (ECF) derived from an established T cell line (STO-2), significantly suppressed the apoptosis of both PB-Eos and BAL-Eos and prolonged their survival. The expression of Fas on PB-Eos was significantly suppressed by ECF-PI9 (18.5 to 7.37%, p < 0.05), whereas ECF-PI9 failed to suppress the Fas expression on BAL-Eos (3.3 to 3.6%). In addition, an ECF with similar physicochemical properties and biological functions was isolated from the BAL fluid of patients with CEP. These data demonstrate differences between PB-Eos and BAL-Eos, and indicate that ECF-PI9 is involved in the pathogenesis of CEP.

Published
1999

2. Seasonal Chronic Cough with Sputum Eosinophilia Caused by Trichosporon cutaneum (Trichosporon asahii)

Author

Y. Nishiura, Shiho Amaike, Masayuki Ando, Masaki Fujimura, Moritaka Suga, Haruhiko Ogawa, Tamotsu Matsuda, and Kazuko Nakagawa-Yoshida

Subjects
Male, Serotype, Allergy, Nasal Provocation Tests, Immunology, Trichosporon asahii, Atopy, Trichosporon, Eosinophilia, medicine, Eosinophilic pneumonia, Humans, Immunology and Allergy, business.industry, Sputum, General Medicine, SPUTUM EOSINOPHILIA, Middle Aged, medicine.disease, respiratory tract diseases, body regions, Chronic cough, Cough, Mycoses, Chronic Disease, Seasons, medicine.symptom, business
Abstract

The case of a 46-year-old man with a chronic cough with sputum eosinophilia (atopic cough) caused by Trichosporon cutaneum serotype II (Trichosporon asahii) is reported. The diagnosis was made with the inhalation challenge test with T. asahii antigen. He was admitted for the diagnosis and treatment of a severe nonproductive cough in the summer season. Although his sputum contained 13% eosinophils of nucleated cells, he did not have bronchial hyperresponsiveness to methacholine or a heightened bronchomotor tone. Bronchodilator therapy was not effective for his cough. His symptoms worsened on returning home, suggesting the existence of some etiologic agent in his house. A high titer of serum anti-Trichosporon antibody was detected and antigen provocation test with the Trichosporon extract was positive: the development of a cough 6 h later and a decrease in the cough threshold to inhaled capsaicin 48 h later (7.85 μM from 31.3 μM prechallenge). This is the first report on a chronic cough with sputum eosinophilia induced by T. cutaneum (T. asahii).

Published
1998

3. Evidence That Allergen-Induced Contraction of Guinea Pig Bronchi Is Mediated in Part by the Release of Tachykinins

Author

Osamu Kawano, Hirotsugu Kohrogi, Tetsuro Yamaguchi, Kazuhiko Fujii, Masayuki Ando, Hajime Iwagoe, and Junji Hamamoto

Subjects
Male, Allergy, Contraction (grammar), Ovalbumin, Bronchoconstriction, Guinea Pigs, Immunology, Tetrodotoxin, Peptide hormone, medicine.disease_cause, Peptides, Cyclic, Drug Hypersensitivity, Pathogenesis, Guinea pig, Allergen, Tachykinins, medicine, Animals, Immunology and Allergy, Protease Inhibitors, biology, business.industry, Glycopeptides, Metalloendopeptidases, General Medicine, Allergens, respiratory system, medicine.disease, respiratory tract diseases, Vagus nerve, biology.protein, business
Abstract

To study the role of tachykinins in allergic responses in the airways of guinea pigs sensitized to ovalbumin (OVA), we examined the bronchial contractile response to allergen in the presence or absence of the tachykinin antagonist FK224 in vitro. Because neutral endopeptidase (NEP) effectively cleaves tachykinins, we incubated bronchial tissues with the NEP inhibitor phosphoramidon (10(-5) M) to maintain the activity of endogenously released tachykinins. Then we added 10(-5)% (10 microns/ml) OVA in the presence or absence of FK224 (10(-5) M). FK224 significantly inhibited OVA-induced contraction plateaued and began to relax, we added 10(-5) M phosphoramidon. In the tissue without FK224, phosphoramidon blocked the relaxation and enhanced the contraction. In contrast, in the tissues treated with FK224, phosphoramidon did not enhance the OVA-induced contraction. The enhancement of the contraction induced by phosphoramidon was not inhibited by the sodium channel blocker tetrodotoxin. These results suggest that (1) allergic response causes release of tachykinin-like substances to induce bronchial contraction in part, (2) these responses are blocked by tachykinin antagonist FK224 and (3) nerve conduction is not necessary for the release of tachykinin-like substances induced by allergic response in the guinea pig bronchus.

Published
1997

4. Dermatophagoides farinae-1-Derived Peptides and HLA Molecules Recognized by T Cells from Atopic Individuals

Author

Masayuki Ando, Takako Matsuoka, Sho Matsushita, Hirotsugu Kohrogi, and Yasuharu Nishimura

Subjects
chemistry.chemical_classification, Allergy, biology, Immunology, Pyroglyphidae, Peptide, General Medicine, T lymphocyte, Human leukocyte antigen, respiratory system, medicine.disease_cause, biology.organism_classification, medicine.disease, Epitope, respiratory tract diseases, Atopy, Allergen, chemistry, immune system diseases, otorhinolaryngologic diseases, medicine, Immunology and Allergy
Abstract

Der f 1, the group I allergen in Dermatophagoides farinae extracts, is a major source of inhalation allergens in Japan. Using the mixture of a panel of overlapping synthetic peptide

Published
1997

5. Contents, Vol. 112, 1997

Author

María Isabel Esteban, Vincenzo Izzo, Luis Caraballo, Masatsugu Kurokawa, Akemi Morita, Tadao Kasahara, Mina Ike, Miki Nyui, Dilia Mercado, Qunwei Zhang, Tamás Gesztesi, Silvia Jiménez, Takako Matsuoka, Takako Oshiro, Thomas Baumruker, Masayuki Ando, A. Eshel, Asil Avjiouglu, Yukinori Kusaka, Y. Waisel, Yasunori Kakuta, Yasuharu Nishimura, Kazuhiro Sato, Pilar García-Ortega, Hideo Kikkawa, Borja Bartolomé, Paolo Colombo, Kana Ueno, Giovanni Locorotondo, Katsuo Ikezawa, B. Grubeck-Loebenstein, Tadashi Ariga, Shigeki Matsubara, Robert N. Pike, Nikolaus Romani, Manfred Auer, Z. Bodnár, Leonardo Puerta, James Travis, Toshiaki Fushimi, Maria Assunta Costa, Ichiro Kobayashi, Laureano Fernández-Távora, Nobuaki Kawamura, Rossana Porcasi, Sho Matsushita, Hiroshi Okayama, E. Kosman, Roberta Cocchiara, M.M. Steger, Hirotsugu Kohrogi, M. Raulf-Heimsoth, Gunther G. Pendl, Nathalie E. Harrer, Alberto Martínez, Ilona Kaszás, Kenta Kawazu, Werner Thumb, Mitsuru Adachi, Beatrice Thurner, Eva E. Prieschl, Giovanni Duro, Fujio Asanuma, Ricardo Palacios, Nobuhiro Maruyama, Montserrat de Molina, Renata Di Fiore, Dennis A. Bagarozzi, Gen Tamura, Atsushi Tame, M. Saurwein-Teissl, Akinori Arimura, Y. Yanagihara, M. Düser, Yukio Sakiyama, Sanae Shimura, Motohiko Okano, Osamu Kaminuma, János M. Jákó, Jorge Martínez, Beatriz Martínez, Hirofumi Furuta, C. Maczek, A. Flagge, Javier Fernández, David G. Marsh, Ken Tomita, Gerold Schuler, Domenico Geraci, Shin-ichi Konno, Yoshiki Gonokami, Kunio Shirato, Angel Vallverdú, A.B. Czuppon, Kiyoshi Yasui, X. Baur, Yoko Furue, and I. Sander

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1997

6. Contents, Vol. 111, Supplement 1, 1996

Author

Matsunobu Suko, Masayuki Ando, Wataru Shimazu, Nobuo Tsuruoka, Hisaho Takahashi, Yoko Nishizaki, Takashi Izumi, Goro Yamada, Hironobu Sugita, Takenori Okada, Nobuo Yamada, Osamu Urayama, Hironori Sagara, Hidemi Nakagawa, Tomokazu Kakazu, Hisao Tomioka, Takao Shimizu, Shoichi Sakamoto, Masaharu Kawabata, Akio Mori, Kazuko Fujita, Mineharu Sugimoto, Takeshi Fukuda, Nobukazu Tomichi, Keiko Umemiya, Kenji Saito, Tomoko Yoshida, Chisei Ra, Hirokazu Okudaira, Tatsuo Kawashima, Shigenori Nakajima, Tadashi Tezuka, Kunihiko Tamaki, Sakumi Shinohara, Ryutaro Matsumura, Keizo Waku, Toshiro Shibuya, Kyoko Yamashiro, Takayuki Sugiura, Hiroshi Saito, Junichi Chihara, Kazuhiko Oki, Haruto Hirano, Hidekazu Yamada, Ikkou Higashimoto, Yoshinori Kawabata, Masaru Kagami, Kiyoshi Takatsu, Yuichi Nakamura, Mitsuomi Hirashima, Osamu Kaminuma, Shinpei Furusawa, Seishi Kishimoto, Tatsuo Yudate, Jiang Li, Moritaka Suga, Ko Okumura, Akira Tsuda, Yukako Arakawa, Toshiyuki Koike, Kenichi Takeuchi, Tsutomu Sakuma, Atsushi Saito, Masashi Shiiba, Hideo Enokihara, Sohei Makino, Takashi Takaiwa, Motoshi Wakugawa, Kenichi Ochiai, Kazusige Futai, Katsuo Ikezawa, Mitsuhiro Osame, Hideo Kikkawa, Nobuyoshi Takahashi, Terumasa Miyamoto, Naoki Saita, Masayoshi Nishimoto, Satoshi Takaki, Tohru Yamanaka, Ryo Izutani, Sapaldiz Team, Hirotsugu Kohrogi, Ryuichiro Maeda, and Masaharu Matsukura

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1996

7. Contents, Vol. 108, Supplement 1, 1995

Author

Masafumi Tsujimoto, Mineharu Sugimoto, Shimpei Furusawa, Hideo Shishido, Koichi Hirai, Atsushi Saito, Kaneshige Yoshida, Kenji Saitou, Kazuhiko Oki, Ken Ohta, Akihiko Terada, Shigeru Takafuji, Mitsuomi Hirashima, Makino S, Kensuke Watanabe, Munetada Haruyama, Haruhito Sugiyama, Masakuni Aoyagi, Nobuo Tsuruoka, Toshiaki Takaishi, Yoshinori Kawabata, Hitoshi Kamiya, Takao Fujisawa, Yutaka Morita, Tadashi Kasahara, Teiji Iwamoto, Mariko Iida, Kenichi Takeuchi, Takayuki Ohtoshi, Hideo Enokihara, Matsunobu Suko, Masayuki Ando, Hironobu Sugita, Hisaho Takahashi, Junichi Chihara, Shigenori Nakajima, Clemens A. Dahinden, Takeshi Fukuda, Takeru Ishikawa, Takahiro Yamamoto, Ken-ichi Manaka, Koji lto, Go Matsuzaki, Yuuichi Nakamura, Yuichi Takahashi, Ikko Higashimoto, Seigou Hirayama, Naoki Saita, Toshiyuki Koike, Shoichi Sakamoto, Misato Miyamasu, Kiyoshi Takatsu, Ikkou Higashimoto, Nobukazu Tomichi, Kenji Tadokoro, Jun Atsuta, Yukako Arakawa, Minoru Sakurai, Dai Kurachi, Yosinori Kawabata, Kanji Watanabe, Hironari Arimura, Masafumi Arima, Tomokazu Kakazu, Kosei Iguchi, Hirokazu Okudaira, and Koji Ito

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1995

8. Contents, Vol. 104, Supplement 1, 1994

Author

Hiroko Nagai, Shimpei Furusawa, Takao Shida, R. Ichimi, Enno Christophers, Yuichi Nakamura, Nobana Hayashi, Ikkou Higashimoto, Minoru Okuda, Dagmar Födinger, Takahiro Yamamoto, Dai Kurachi, Akiyoshi Konno, Akikatsu Kataura, M. Sakurai, Naoko Yoshida, Mahboob Hossain, Akio Mori, Oliver Kilgus, Kenji Tadokoro, Dieter Maurer, Hirokazu Okudaira, Kenichi Ochiai, Kazuyoshi Watanabe, Minoru Miyasato, Daniel G. Tenen, Michiko Ishizaki, Mika Ueno, Setsuya Fukuda, Jean-Pierre Kinet, Koji lto, Naoki Saita, Shigeki Nagashima, Hisao Tomioka, Osamu Kaminuma, Kiyoshi Togawa, Yoji Iikura, Kano Taguchi, Naohisa Kitamura, Takeshi Mishima, Koji Shirotori, Takashi Yamada, Yasuhiro Samejima, Hideo Shishido, Itsuko Miura, Yuji Kikuchi, Matsunobu Suko, Masayuki Ando, Georg Stingl, Kiyoshi Takatsu, Tomokazu Kakazu, Armin Rieger, Yohnosuke Kobayashi, Shigenori Nakajima, Tohru Kimura, Takafumi Etoh, Jun Atsuta, Ryouji Ichimi, Shigeru Takafuji, Fumiko Juji, Shingo Tsuda, Keisuke Masuyama, Yoko Nishizaki, H. Kamiya, Steven J. Ackerman, Hidemi Nakagawa, Mitsuomi Hirashima, Binghe Wang, Hiroya Takashima, Nobuhisa Terada, Shoso Yamamoto, J. Atsuta, Nobuo Tsuruoka, Jens-M. Schröder, Susumu Tsurufuji, Takao Fujisawa, Koji Asakura, Morie Sekiguchi, Go Matsuzaki, Keiko Kato, T. Fujisawa, Yuji Yamaguchi, Clemens A. Dahinden, Takeru Ishikawa, Junichi Chihara, Satoshi Takaki, Hiroko Saito, Hideo Enokihara, Yoshio Okubo, Norihisa Ogata, Yoshikazu Kameyoshi, and Makoto Yoshida

Subjects
Materials science, Immunology, Immunology and Allergy, General Medicine
Published
1994

9. Contents, Vol. 95, 1991

Author

Masayuki Ando, B.H. Davies, B. Björkstén, Joel M. Bernstein, Manel Jordana, John Savala, K. Katamura, Lars Häggblom, Bjørn Haneberg, D. Michaelis, Shukuro Araki, G. Kunkel, Erika Schläpfer, John S. Abrams, Laurie Churchill, Anna Pawlowicz, Chaoyuan Chen, J.H. Skerritt, S. Ahlstedt, David Nadal, I. Penttila, K. Dierks, J.M. Devery, Carlo Vancheri, Staffan Jansson, L.K. Poulsen, K. Ishizaka, N.R. Kitteringham, R. Wahl, Theoharis C. Theoharides, J.K. Kleine-Tebbe, Curt Reynolds, Jack Gauldie, Takashi Tsuda, Svein Kolmannskog, David Proud, Takayuki Ohtoshi, Masaru Yoshinaga, M.P. Borres, V. Bender, G. Varnai, Boris Albini, Katerina Marathias, Robert M. Naclerio, Jerry Dolovich, Mona Lambracht-Hall, Dag Hvidsten, K. Neftel, B.K. Park, Jacqueline A. Pongracic, S. Knospe, W.R. Williams, E. Köhler, H. Wanka, W. Förster, J.B. Clarke, Pearay L. Ogra, Lars-Olof Mentzing, Naoki Saita, and Judah A. Denburg

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991

10. Expression of Apoptosis-Related Antigen on Eosinophils in Chronic Eosinophilic Pneumonia

Author

Tohru Yamanaka, Mitsuhiro Matsumoto, Masayuki Ando, Naoki Saita, Moritaka Suga, Hirotsugu Kohrogi, and Mitsuomi Hirashima

Subjects
Adult, Male, Chemotactic Factors, Eosinophil, Immunology, Apoptosis, Stimulation, Antigen, Eosinophilic pneumonia, Humans, Immunology and Allergy, Medicine, fas Receptor, Pulmonary Eosinophilia, Interleukin 5, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, respiratory system, Colony-stimulating factor, medicine.disease, Eosinophils, Chemotaxis, Leukocyte, Bronchoalveolar lavage, Proto-Oncogene Proteins c-bcl-2, Chronic Disease, Female, Chronic eosinophilic pneumonia, business, Bronchoalveolar Lavage Fluid
Abstract

We examined the expression of apoptosis-related antigens Fas and bcl-2 on eosinophils from peripheral blood (PB) and bronchoalveolar lavage (BAL) in patients with chronic eosinophilic pneumonia (CEP). The expression of those antigens was assessed before and after culture with or without eosinophil chemotactic factors derived from an established T-cell line (STO-2-derived ECFs; ECF-PI5, 6, 7, 8, and 9), granulocyte-macrophage colony stimulating factor, and interleukin 5 (IL-5). We found that the expression of these antigens on eosinophils from PB increased after 24 h culture without any stimulation. In contrast, little or no change was observed even after 24 h culture in eosinophils from BAL. All STO2-derived ECFs and IL-5 suppressed Fas expression on eosinophils from PB. Furthermore, we found that eosinophils which were attracted by ECF-PI9 expressed Fas and bcl-2 more highly than those attracted by other ECFs and IL-5. Such a heterogeneous response of eosinophils to respective ECFs suggests the possibility of a heterogeneous population of eosinophils in patients with CEP.

Published
1997

11. Contents, Vol. 114, Supplment 1, 1997

Author

Somei Kojima, Yoshiki Miyachi, Hideo Kikkawa, Kosei Iguchi, Taishi Hata, Takao Shimizu, Wataru Shimadzu, Hirohito Kita, Akira Tsuda, Matsunobu Suko, Masayuki Ando, Georg Stingl, Norihisa Ogata, Kunio Sano, Hironori Sagara, Hajime Oyamada, Junich Chihara, Yuji Shimizu, Shinji Motojima, Mitsuomi Hirashima, Naoki Matsumoto, Hiroyuki Kobayashi, Makoto Nagata, Toshiyuki Koike, Kohei Yamauchi, Mitsuhiro Matsumoto, Tadashi Tezuka, Gen Tamura, Masao Tomonaga, Toru Horie, Hidekazu Yamada, Hirotsugu Kohrogi, Masatomo Mori, Yoshimichi Okayama, Julie B. Sedgwick, Keizo Waku, Akio Mori, Masaharu Matsukura, Hiroo Amano, Jong Yil Chai, Osamu Ishikawa, Martin K. Church, Shinpei Furusawa, Takashi Koseki, Takeshi Fukuda, Hideo Enokihara, Sohei Makino, Masaaki Honma, Osamu Kaminuma, Tohru Yamanaka, Masatsugu Kurokawa, Yumiko Kamada, Mitsuru Adachi, Hirokazu Okudaira, Hirokazu Nakajima, Takayuki Sugiura, Yuichi Nakamura, Takeshi Nara, Gerald J. Gleich, Hiroshi Sakagami, Tatsuo Yudate, Taku Kouro, Takashi Izumi, Hiromichi Noda, Masahiko Kato, Kazuaki Naito, Yuvadee Mahakunkijcharoen, Moritaka Suga, Osamu Urayama, Kunio Shirato, Yoshio Osada, Takao Fujisawa, Fumio Kokubu, Jun Atsuta, Kinji Tateishi, Akihiko Terada, Yuji Kikuchi, Leone K. Ashman, Naotomo Kanbe, Hisahiro Tokunaga, Takeru Ishikawa, Akihiro Morikawa, Masako Seki, Motohiro Kurosawa, William W. Busse, Kiyoshi Takatsu, Seishi Kishimoto, Yasushi Igarashi, Eun-Hee Shin, Yoichiro Matsushima, Hitoshi Kamiya, Naoki Saita, Stephan T. Holgate, Hiroki Hoshi, Minoru Sakurai, Minoru Takeda, Junichi Chihara, and Kenji Saito

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1997

12. Heterogeneity of Eosinophils in Chronic Eosinophilic Pneumonia

Author

Masayuki Ando, Hirotsugu Kohrogi, Tohru Yamanaka, Naoki Saita, Mineharu Sugimoto, Moritaka Suga, and Mitsuomi Hirashima

Subjects
Antigens, Differentiation, T-Lymphocyte, Integrins, Pathology, medicine.medical_specialty, Chemotactic Factors, Eosinophil, Immunology, Population, Receptors, Lymphocyte Homing, Macrophage-1 Antigen, Integrin alpha4beta1, Antigen, Antigens, CD, Eosinophilic pneumonia, Humans, Immunology and Allergy, Medicine, Lectins, C-Type, Pulmonary Eosinophilia, education, education.field_of_study, L-Lactate Dehydrogenase, medicine.diagnostic_test, biology, business.industry, Respiratory disease, Chemotaxis, General Medicine, respiratory system, Eosinophil, medicine.disease, Eosinophils, Chemotaxis, Leukocyte, Bronchoalveolar lavage, medicine.anatomical_structure, Integrin alpha M, Chronic Disease, biology.protein, business, Cell Adhesion Molecules
Abstract

It has previously been shown that patients with chronic eosinophilic pneumonia can be divided into 2 groups according to the chemotactic response of their eosinophils to 5 different eosinophil chemotactic factors (ECFs) and laboratory findings. In contrast, eosinophils obtained by bronchoalveolar lavage from both groups responded to all 5 ECFs. The correlation between the two groups and the expression of several antigens (VLA-4, CD69, ICAM-1 and CD11b) on eosinophils. The VLA-4 expression of group 1 eosinophils was higher than that of group 2 eosinophils. More interestingly, eosinophils that migrated towards ECF-PI9 expressed less CD69 than those that migrated towards other STO-2-derived ECF. The heterogeneous response of eosinophils to STO-2-derived ECFs suggests that the population of eosinophils is heterogeneous.

Published
1996

13. Chemotactic Heterogeneity of Eosinophils in Kimura’s Disease

Author

Makoto Yoshida, Naoki Saita, Masayuki Ando, Mika Ueno, Tohru Kimura, and Mitsuomi Hirashima

Subjects
medicine.medical_specialty, Chemotactic Factors, Eosinophil, T cell, Immunology, Random migration, Dermatitis, Atopic, Pathogenesis, Internal medicine, medicine, Humans, Immunology and Allergy, business.industry, Angiolymphoid Hyperplasia with Eosinophilia, Chemotaxis, General Medicine, Atopic dermatitis, respiratory system, Eosinophil, medicine.disease, Eosinophil Chemotactic Factors, Eosinophils, Chemotaxis, Leukocyte, Endocrinology, medicine.anatomical_structure, Kimura's disease, business
Abstract

We evaluated the chemotactic heterogeneity of eosinophils in Kimura's disease. Patients with Kimura's disease were divided into two groups according to their clinical findings: one group had no other symptoms (KD), and another was accompanied with atopic dermatitis (KD + AD). The chemotactic response of eosinophils from two groups to 5 eosinophil chemotactic factors (ECF) derived from STO-2, an established T cell line. Eosinophils from KD were attracted only by ECF-PI5 and PI6 but not by ECF-PI7, PI8 and PI9. On the other hand, eosinophils from KD + AD responded to all 5 ECF. Eosinophils were further fractionated into normodense and hypodense eosinophils, and assessed for their chemotactic response. We thus found that there was little essential difference in their chemotactic responses to STO-2-derived ECF except ECF-PI9, though random migration of hypodense eosinophils was enhanced. The hypothesis that hypodense eosinophils are in the activated form was not always true, especially in the chemotactic response to ECF.

Published
1994

14. Chemotactic heterogeneity of eosinophils in idiopathic pulmonary eosinophilia

Author

Masayuki Ando, Seigou Hirayama, Naoki Saita, Mineharu Sugimoto, and Mitsuomi Hirashima

Subjects
Adult, Male, Pathology, medicine.medical_specialty, T cell, Immunology, Pathogenesis, Eosinophilic, medicine, Eosinophilic pneumonia, Immunology and Allergy, Humans, Pulmonary Eosinophilia, Aged, Chemotactic Factors, business.industry, Respiratory disease, Chemotaxis, General Medicine, respiratory system, Eosinophil, medicine.disease, Eosinophils, Chemotaxis, Leukocyte, medicine.anatomical_structure, Female, business
Abstract

Heterogeneity in the chemotactic response of eosinophils to 5 T cell line eosinophilic chemotactic factors (ECFs) was assessed in 5 patients with idiopathic pulmonary eosinophilia. Eosinophils from 2 patients responded to all 5 ECFs (group 1), whereas eosinophils from the other 3 patients responded to ECF-PI 5, PI 6, PI 7 and PI 8 but failed to respond to ECF-PI 9 (group 2). It was further found that group 1 showed an elevated level of lactate dehydrogenase and a positive tuberculin reaction, whereas group 2 showed neither. The effects of steroid therapy on the chemotactic responses of eosinophils were also examined. In group 1, the chemotactic response of eosinophils to ECF-PI 9 was significantly diminished after therapy; in contrast it was elevated in group 2. This change was accompanied by resolution of both clinical symptoms and pulmonary infiltration of eosinophils. These findings suggest that pulmonary eosinophilia can be divided into two types on the basis of eosinophil chemotactic response and laboratory findings. The heterogeneous responses of eosinophils to ECFs may provide a useful marker for classification of pulmonary eosinophilia and evaluation of therapy.

Published
1995

15. Subject Index, Vol. 112, 1997

Author

Yoshiki Gonokami, Renata Di Fiore, M.M. Steger, Hirotsugu Kohrogi, Gerold Schuler, Werner Thumb, Kiyoshi Yasui, Mina Ike, Nobuaki Kawamura, David G. Marsh, M. Raulf-Heimsoth, Takako Oshiro, Fujio Asanuma, Vincenzo Izzo, Toshiaki Fushimi, Thomas Baumruker, Masayuki Ando, Hirofumi Furuta, X. Baur, Yoko Furue, Dennis A. Bagarozzi, Jorge Martínez, Y. Waisel, Akemi Morita, Hideo Kikkawa, C. Maczek, B. Grubeck-Loebenstein, Shigeki Matsubara, Javier Fernández, Robert N. Pike, Nikolaus Romani, A. Flagge, Alberto Martínez, Hiroshi Okayama, Paolo Colombo, Yasuharu Nishimura, Akinori Arimura, Z. Bodnár, Tadashi Ariga, Manfred Auer, María Isabel Esteban, Mitsuru Adachi, Miki Nyui, Leonardo Puerta, James Travis, Rossana Porcasi, Ichiro Kobayashi, Ken Tomita, Silvia Jiménez, A. Eshel, Takako Matsuoka, Asil Avjiouglu, Tadao Kasahara, Pilar García-Ortega, Luis Caraballo, Masatsugu Kurokawa, Roberta Cocchiara, Beatriz Martínez, Ilona Kaszás, Kunio Shirato, Angel Vallverdú, Y. Yanagihara, A.B. Czuppon, Dilia Mercado, Tamás Gesztesi, Yukio Sakiyama, Sanae Shimura, Yukinori Kusaka, I. Sander, Maria Assunta Costa, Eva E. Prieschl, Qunwei Zhang, Domenico Geraci, Shin-ichi Konno, Giovanni Duro, Borja Bartolomé, Ricardo Palacios, Beatrice Thurner, Yasunori Kakuta, Laureano Fernández-Távora, Katsuo Ikezawa, Kenta Kawazu, Kazuhiro Sato, Sho Matsushita, János M. Jákó, Gunther G. Pendl, Nathalie E. Harrer, Montserrat de Molina, Atsushi Tame, Gen Tamura, M. Saurwein-Teissl, M. Düser, Kana Ueno, Giovanni Locorotondo, E. Kosman, Nobuhiro Maruyama, Motohiko Okano, and Osamu Kaminuma

Subjects
Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1997

16. Subject Index Vol. 120, Suppl. 1, 1999

Author

Ryo Atsuta, Tadashi Tezuka, Kana Ueno, Hirotsugu Kohrogi, Enno Christophers, Hitoshi Kamiya, Masaharu Matsukura, Motohiro Ito, Itsuo Iwamoto, Yoshimi Kobayashi, Kenji Ishihara, Hiroshi Wakiguchi, Norihiro Saito, Akinori Mochizuki, Hideko Kobayashi, Mitsuhiro Osame, Kazuo Ohuchi, Mitsuru Mochizuki, Hiroyuki Kayaba, Bruce S. Bochner, Kohei Honda, Hiroko Watanabe, Takao Fujisawa, Kenichi Ochiai, Kayako Hira, Hirokazu Kimura, Shoso Yamamoto, Yumiko Kamada, Toshiyuki Nishimuta, Yoshinosuke Fukuchi, Kazumoto Katagiri, Takeru Ishikawa, Tohru Yamanaka, Hideoki Ogawa, Tadanori Hashimoto, J. Suzuki, Hiroshi Matsuda, Sohei Makino, Shigenori Nakajima, Tomoe Kuwasaki, Masahiko Kato, Koichi Mitsuishi, Yutaka Hatano, Kazuo Akiyama, Kunio Sekine, A. Tsukadaira, Takeaki Nittoh, Y. Okubo, Yoshiko Kato, Susumu Takayasu, Yasushi Saito, Tetsushi Unno, S. Horie, Masahide Miyamoto, Koji Ogawa, Atsuhito Nakao, S. Takashi, Hidekazu Yamada, M. Sekiguchi, M. Isobe, T. Momose, Kenji Minoguchi, Matsunobu Suko, Masayuki Ando, Kosei Iguchi, Katsuo Ikezawa, Osamu Kaminuma, Masaharu Kawabata, Mitsuomi Hirashima, Kenji Matsumoto, Kenichi Tokuyama, Naoki Shimojo, Yoshiyuki Yamada, Hajime Oyamada, Satoshi Miike, Chisei Ra, Hirokazu Okudaira, Kiyoko Wada, Mizuko Mamura, Tatsuo Yudate, Ko Okumura, Chang-Hao Cui, Ikkou Higashimoto, Miho Omura, Takeshi Fukuda, Masahiko Aoyagi, Takanobu Kurashige, Rieko Kameda, Yoichi Kohno, Naoki Saita, Shinji Kurashimo, Youichi Motegi, Norihoro Saito, Ikuko Satoh, Hideaki Yamamoto, Atsushi Tachibana, Akiyoshi Konno, Akio Mori, Masaki Hiraguri, Takuji Shirasawa, Takafumi Uchida, Jens-M. Schröder, Susumu Tsurufuji, Makoto Nagata, Mitsuru Adachi, Hideo Kikkawa, Hirohito Kita, Yasurou Kohno, Akihiko Terada, Hisao Tomioka, Kayo Tsukahara, Hajime Suto, Akihiro Morikawa, and Junichi Chihara

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1999

17. Author Index / Subject Index

Author

Atsushi Saito, Satoshi Takaki, Nobuo Tsuruoka, Matsunobu Suko, Masayuki Ando, Toshiyuki Koike, Motoshi Wakugawa, Ko Okumura, Nobuo Yamada, Wataru Shimazu, Ryuichiro Maeda, Shoichi Sakamoto, Yukako Arakawa, Kenichi Takeuchi, Hisaho Takahashi, Tohru Yamanaka, Junichi Chihara, Tadashi Tezuka, Akio Mori, Mineharu Sugimoto, Kenji Saito, Hironobu Sugita, Sakumi Shinohara, Hirotsugu Kohrogi, Sapaldiz Team, Hidemi Nakagawa, Chisei Ra, Shigenori Nakajima, Keizo Waku, Takenori Okada, Takeshi Fukuda, Masaharu Matsukura, Kazuhiko Oki, Hideo Kikkawa, Haruto Hirano, Hidekazu Yamada, Akira Tsuda, Osamu Kaminuma, Tomoko Yoshida, Toshiro Shibuya, Hisao Tomioka, Takao Shimizu, Kunihiko Tamaki, Sohei Makino, Ryutaro Matsumura, Shinpei Furusawa, Terumasa Miyamoto, N. Tomichi, Takayuki Sugiura, Nobuyoshi Takahashi, Masashi Shiiba, Hideo Enokihara, Katsuo Ikezawa, Masaharu Kawabata, Kiyoshi Takatsu, Takashi Takaiwa, Seishi Kishimoto, Kenichi Ochiai, Tomokazu Kakazu, Hirokazu Okudaira, Mitsuomi Hirashima, Tatsuo Yudate, Moritaka Suga, Takashi Izumi, Osamu Urayama, Yoko Nishizaki, Goro Yamada, Kazuko Fujita, Jiang Li, K Umemiya, Hiroshi Saito, Hironori Sagara, Ryo Izutani, Kazusige Futai, Naoki Saita, Masayoshi Nishimoto, Yoshinori Kawabata, Mitsuhiro Osame, Kyoko Yamashiro, Ikkou Higashimoto, Yuichi Nakamura, M Kagami, Tsutomu Sakuma, and Tatsuo Kawashima

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
1996

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