1. Food Allergens Transformed into Tolerogens
- Author
-
H. Borel, Y. Borel, Ulf Dahlgren, L. Å. Hanson, Esbjörn Telemo, R. Fritsche, and A. Dahlman-Höglund
- Subjects
Male ,Immunoconjugates ,Ovalbumin ,medicine.medical_treatment ,Immunology ,Antigen presentation ,medicine.disease_cause ,Immunoglobulin G ,Rats, Sprague-Dawley ,Allergen ,Immune system ,medicine ,Animals ,Immunology and Allergy ,B cell ,Desensitization (medicine) ,Antigen Presentation ,biology ,business.industry ,General Medicine ,Allergens ,respiratory system ,Rats ,respiratory tract diseases ,medicine.anatomical_structure ,Desensitization, Immunologic ,Antibody Formation ,Allergic response ,biology.protein ,Immunization ,business ,Food Hypersensitivity - Abstract
Antigen presentation determines immunologic outcome, and by modifying the presentation of allergen to the host one can prevent an allergic response. Under certain conditions, covalent linkage, of ovalbumin to rat IgG, a molecule already tolerated by the host, can make a protein-IgG conjugate which down-regulates the immune response to this food allergen. The suppression is allergen specific. It affects both T and B cell immune responses. Administration of allergens linked to isologous IgG may provide a novel strategy for allergy prevention.
- Published
- 1995