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1. Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report.

Author

Iwatsuka K, Kikuta D, Shibuya H, Ogawa M, Gotoda T, Moriyama M, Nakagawara H, Hemmi A, and Yamao K

Subjects
Albumins therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Autopsy, Deoxycytidine analogs & derivatives, Female, Humans, Middle Aged, Paclitaxel therapeutic use, Treatment Outcome, Gemcitabine, Adenocarcinoma drug therapy, Meningeal Carcinomatosis drug therapy, Pancreatic Neoplasms drug therapy
Abstract

A 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, LMC from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabine and whole-brain radiation. Shortly thereafter, she developed a severe consciousness impediment and died. A pathological autopsy showed adenocarcinoma in a wide area of the leptomeninges.

Published
2021
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