1. Nephrotic Syndrome with Thrombocytopenia, Lymphadenopathy, Systemic Inflammation, and Splenomegaly
- Author
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Fuyuko Akagaki, Ryoichi Arima, Yoshito Yamaguchi, Aya Nakamori, and Toshihiro Sugiura
- Subjects
Pathology ,medicine.medical_specialty ,Nephrotic Syndrome ,Tubular atrophy ,030232 urology & nephrology ,Lymphadenopathy ,Inflammation ,Case Report ,Systemic inflammation ,Kidney ,idiopathic multicentric Castleman Disease ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,renal dysfunction ,Biopsy ,Internal Medicine ,Medicine ,Humans ,Renal Insufficiency ,medicine.diagnostic_test ,business.industry ,urogenital system ,General Medicine ,TAFRO syndrome ,small vessel lesions ,Middle Aged ,medicine.disease ,Thrombocytopenia ,Pathophysiology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Splenomegaly ,Female ,medicine.symptom ,business ,Nephrotic syndrome - Abstract
Nephrotic syndrome can be caused by various diseases, from primary kidney diseases to systemic diseases. A kidney biopsy is useful for confirming the causes of nephrotic syndrome and in its management. We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency. A kidney biopsy showed endothelial swelling with mild interstitial fibrosis and tubular atrophy. This case met the diagnostic criteria for TAFRO syndrome. Little is known about TAFRO syndrome, especially in relation to the associated kidney pathophysiology. The accumulation of a greater number of cases in which the kidney biopsy findings are investigated is needed to clarify the pathogenesis of kidney involvement in this condition.
- Published
- 2017