1. Community-acquired Disseminated Exophiala dermatitidis Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease
- Author
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Yasushi Takamatsu, Hiromi To, Yuri Yamashiro, Yasumasa Kawano, Koji Kusaba, Michio Masaki, Eisaburo Sueoka, Morishige Takeshita, Atsushi Togawa, Midori Kumagawa, Katsumi Kobata, Hiroyasu Ishikura, Tohru Takata, Akihiko Shirahashi, Satoshi Takagi, Kazuo Tamura, and Eiichi Sato
- Subjects
biology ,business.industry ,medicine.medical_treatment ,Micafungin ,Necrotising fasciitis ,General Medicine ,Hematopoietic stem cell transplantation ,medicine.disease ,biology.organism_classification ,Transplantation ,Phaeohyphomycosis ,surgical procedures, operative ,Graft-versus-host disease ,immune system diseases ,Immunology ,Internal Medicine ,Medicine ,business ,Exophiala dermatitidis ,Mycosis ,medicine.drug - Abstract
We herein report a case of systemic phaeohyphomycosis by Exophiala dermatitidis (E. dermatitidis) with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The patient had been taking oral corticosteroids for years to control the GVHD. Yeast-like fungi were identified in a blood culture, so treatment with micafungin (150 mg/day) was begun, with no improvement. The patient passed away on hospital Day 12. A sequence analysis of rRNA revealed the isolate to be E. dermatitidis. This report brings attention to an emerging mycosis of community-acquired Exophiala species infection in the very-late phase after allogenic HSCT in patients with chronic GVHD.
- Published
- 2019