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2 results on '"Koji Kusaba"'

1. Community-acquired Disseminated Exophiala dermatitidis Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease

Author

Yasushi Takamatsu, Hiromi To, Yuri Yamashiro, Yasumasa Kawano, Koji Kusaba, Michio Masaki, Eisaburo Sueoka, Morishige Takeshita, Atsushi Togawa, Midori Kumagawa, Katsumi Kobata, Hiroyasu Ishikura, Tohru Takata, Akihiko Shirahashi, Satoshi Takagi, Kazuo Tamura, and Eiichi Sato

Subjects
biology, business.industry, medicine.medical_treatment, Micafungin, Necrotising fasciitis, General Medicine, Hematopoietic stem cell transplantation, medicine.disease, biology.organism_classification, Transplantation, Phaeohyphomycosis, surgical procedures, operative, Graft-versus-host disease, immune system diseases, Immunology, Internal Medicine, Medicine, business, Exophiala dermatitidis, Mycosis, medicine.drug
Abstract

We herein report a case of systemic phaeohyphomycosis by Exophiala dermatitidis (E. dermatitidis) with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The patient had been taking oral corticosteroids for years to control the GVHD. Yeast-like fungi were identified in a blood culture, so treatment with micafungin (150 mg/day) was begun, with no improvement. The patient passed away on hospital Day 12. A sequence analysis of rRNA revealed the isolate to be E. dermatitidis. This report brings attention to an emerging mycosis of community-acquired Exophiala species infection in the very-late phase after allogenic HSCT in patients with chronic GVHD.

Published
2019

2. Disseminated Nocardiosis Caused by Nocardia concava with Acute Respiratory Failure and Central Nervous System Involvement Treated with Linezolid

Author

Shinichiro Hayashi, Hitomi Umeguchi, Katsukiyo Yazawa, Shinya Kimura, Naomi Kobayashi, Naoko Sueoka-Aragane, Zenzo Nagasawa, Koji Kusaba, Natsuko Naganobu, and Tohru Gonoi

Subjects
Male, Pathology, medicine.medical_specialty, Central nervous system, Cutis, Nocardia Infections, Minocycline, Microbial Sensitivity Tests, Nocardia, Immunocompromised Host, chemistry.chemical_compound, Central Nervous System Diseases, Acetamides, Trimethoprim, Sulfamethoxazole Drug Combination, Internal Medicine, Ventriculitis, Humans, Medicine, Oxazolidinones, Aged, business.industry, Linezolid, Disseminated nocardiosis, General Medicine, bacterial infections and mycoses, medicine.disease, Trimethoprim, Anti-Bacterial Agents, medicine.anatomical_structure, chemistry, Acute Disease, Respiratory Insufficiency, business, Meningitis, Subcutaneous tissue, medicine.drug
Abstract

Nocardia concava was identified as a new species in 2005; however, the clinical manifestations of Nocardia concava infection have yet to be clarified. We herein present the case of an immunosuppressed patient who developed disseminated nocardiosis caused by N. concava with multiple abscesses in the lungs, cutis, subcutaneous tissue, skeletal muscles and kidneys accompanied by central nervous system involvement, including meningitis and ventriculitis. The patient was cured with appropriate treatment including linezolid after testing for susceptibility. Linezolid should be considered as an alternative agent for treating disseminated nocardiosis because of its effective distribution to multiple sites.

Published
2012

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