1. Spread through air spaces is an independent predictor of recurrence in stage III (N2) lung adenocarcinoma
- Author
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Masaki Anraku, Kosuke Kashiwabara, Kazuhiro Nagayama, Masaaki Sato, Yuriko Terada, Tsuyoshi Takahashi, Shigeki Morita, Jun-ichi Nitadori, Jun Nakajima, and Aya Shinozaki-Ushiku
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Lymphovascular invasion ,Adenocarcinoma of Lung ,Independent predictor ,Gastroenterology ,Japan ,Risk Factors ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Stage (cooking) ,Pneumonectomy ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,Lung ,business.industry ,Hazard ratio ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Survival Rate ,medicine.anatomical_structure ,Adenocarcinoma ,Female ,Surgery ,Neoplasm Recurrence, Local ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES Spread through air space (STAS) is recognized as a pattern of invasion in lung adenocarcinoma and has been reported to be a predictor of recurrence and survival in patients with early-stage lung adenocarcinoma. However, this parameter has not been studied well in stage III (N2) lung adenocarcinoma. In this study, we evaluated the association between STAS invasion patterns and recurrence and survival in stage III (N2) lung adenocarcinoma. METHODS We retrospectively reviewed data from 76 patients at University of Tokyo with stage III (N2) lung adenocarcinoma who underwent surgery from August 1998 to December 2013. Statistical analysis was performed to determine the impact of STAS invasion clinicopathological features and clarify the relationship between this pattern of invasion and survival. RESULTS Tumour STAS was observed in 46 of 76 patients (60.5%) and was significantly associated with the presence of lymphatic invasion (P CONCLUSIONS The presence of STAS invasion pattern is a significant risk factor for recurrence in stage III (N2) lung adenocarcinoma.
- Published
- 2019