1. The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis
- Author
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Mingxiao Yang PhD, Hui Wang PhD, Yi Lily Zhang DPT, Furong Zhang PhD, Xiaotong Li PhD, Soo-Dam Kim PhD, Yalan Chen MMed, Jiyao Chen MMed, Susan Chimonas PhD, Deborah Korenstein MD, and Jun J. Mao MD, MSCE
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Sleep disturbances are common and bothersome among cancer and noncancer populations. Suanzaoren ( Ziziphi Spinosae Semen ) is commonly used to improve sleep, yet its efficacy and safety are unclear. Methods: We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized trials of Suanzaoren . We included randomized trials comparing Suanzaoren to placebo, medications, cognitive behavioral therapy (CBT), or usual care for improving sleep outcomes in cancer and noncancer patients with insomnia or sleep disturbance. We performed a risk of bias analysis following Cochrane guidelines. Depending on heterogeneity, we pooled studies with similar comparators using fixed- and random-effects models. Results: We included participants with insomnia disorder (N = 785) or sleep disturbance (N = 120) from 9 trials. Compared with placebo, Suanzaoren led to significant subjective sleep quality improvements in participants with insomnia and patients with sleep disturbance combined (standard mean difference −0.58, 95% CI −1.04, −0.11; P
- Published
- 2023
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