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Start Over Author "Wea-Lung Lin" Journal integrative cancer therapies
3 results on '"Wea-Lung Lin"'

1. The Protective Role of GMI, an Immunomodulatory Protein From , on 5-Fluorouracil-Induced Oral and Intestinal Mucositis

Author

Che-Hsing Li, Jiunn-Liang Ko, Chu-Chyn Ou, Wea-Lung Lin, Cheng-Chieh Yen, Chih-Ting Hsu, and Yu-Ping Hsiao

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

5-Fluorouracil (5-FU) is used in the treatment of head and neck cancer patients. However, adverse effects experienced such as mucositis and poor appetite may lead to interruption in chemotherapy. The aim of this study is to evaluate the efficacy of GMI, one fungal immunomodulatory protein found in Ganoderma microsporum , for mucositis induced by 5-FU in a mouse model. Mice were administered 5-FU intraperitoneally for 4 days per cycle for a total of 2 chemotherapy cycles. In addition, mice were pretreated with GMI or phosphate-buffered saline 3 days before 5-FU intraperitoneal injection and daily until day 14. On histological analysis, GMI prevented 5-FU-induced damage to the intestinal mucosa and tongue epithelium. We also demonstrated that GMI enhanced the cytotoxicity of 5-FU in 2 oral cancer cell lines, while GMI could not promote this effect in an oral normal cell. In conclusion, GMI alleviates 5-FU-induced damage and decelerates cell death in normal alimentary tract tissue.

Published
2019
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2. The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis

Author

Cheng-Chieh Yen, Che-Hsing Li, Chih-Ting Hsu, Chu-Chyn Ou, Yu-Ping Hsiao, Jiunn-Liang Ko, and Wea-Lung Lin

Subjects
0301 basic medicine, Male, Mucositis, Programmed cell death, Antimetabolites, Antineoplastic, medicine.medical_treatment, Intraperitoneal injection, Apoptosis, Pharmacology, 03 medical and health sciences, Mice, 0302 clinical medicine, Intestinal mucosa, immunomodulatory protein, medicine, Animals, Immunologic Factors, Microsporum, 5-fluorouracil, Intestinal Mucosa, Cytotoxicity, Adverse effect, Chemotherapy, Mice, Inbred BALB C, business.industry, Ganoderma, medicine.disease, Disease Models, Animal, 030104 developmental biology, Complementary and alternative medicine, Oncology, Fluorouracil, 030220 oncology & carcinogenesis, business, medicine.drug, Research Article
Abstract

5-Fluorouracil (5-FU) is used in the treatment of head and neck cancer patients. However, adverse effects experienced such as mucositis and poor appetite may lead to interruption in chemotherapy. The aim of this study is to evaluate the efficacy of GMI, one fungal immunomodulatory protein found in Ganoderma microsporum, for mucositis induced by 5-FU in a mouse model. Mice were administered 5-FU intraperitoneally for 4 days per cycle for a total of 2 chemotherapy cycles. In addition, mice were pretreated with GMI or phosphate-buffered saline 3 days before 5-FU intraperitoneal injection and daily until day 14. On histological analysis, GMI prevented 5-FU-induced damage to the intestinal mucosa and tongue epithelium. We also demonstrated that GMI enhanced the cytotoxicity of 5-FU in 2 oral cancer cell lines, while GMI could not promote this effect in an oral normal cell. In conclusion, GMI alleviates 5-FU-induced damage and decelerates cell death in normal alimentary tract tissue.

Published
2019

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