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Your search keyword '"Jaworski, Jacek"' showing total 2 results
Start Over Author "Jaworski, Jacek" Journal inorganic chemistry
2 results on '"Jaworski, Jacek"'

1. Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: Syntheses, characterization and biological imaging applications

Author

Nolan, Elizabeth M., Jaworski, Jacek, Racine, Maryann E., Sheng, Morgan, and Lippard, Stephen J.

Subjects
Pyrrole -- Chemical properties, Pyrrole -- Optical properties, Zinc -- Chemical properties, Zinc -- Optical properties, Chemistry
Abstract

The sensor platform of zinpyr 4 (ZP4) through pyrrole-for-pyridyl substitution is modified and the effects of this variation on both photophysical and metal-binding properties are evaluated. The utility of aniline-based ZP probes for select biological imaging applications are investigated.

Published
2006

2. ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy

Author

Chang, Christopher J., Nolan, Elizabeth M., Jaworski, Jacek, Okamoto, Ken-Ichi, Hayashi, Yasunori, Sheng, Morgan, and Lippard, Stephen J.

Subjects
Aniline -- Structure, Fluorescein -- Structure, Microscope and microscopy -- Usage, Chemistry
Abstract

The synthesis of a difluorofluorescein monocarboxaldehyde platform and its use for preparing ZP8, a new member of the Zinpyr family of neuronal Zn(super 2+) sensors, are described. It was found that by combining an aniline photoinduced electron transfer (PET) switch and an electron-withdrawing fluorescein scaffold, ZP8 displays reduced background fluorescence and improved dynamic range compared to previous ZP probes.

Published
2004

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