1. Metal-Organic Framework Showing Selective and Sensitive Detection of Exogenous and Endogenous Formaldehyde
- Author
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Vishal Trivedi, Ena Sharma, Shyam Biswas, and Soutick Nandi
- Subjects
Surface Properties ,Formaldehyde ,Hydrazone ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Photoinduced electron transfer ,Fluorescence ,Inorganic Chemistry ,chemistry.chemical_compound ,Spectroscopy, Fourier Transform Infrared ,Tumor Cells, Cultured ,Moiety ,Humans ,Physical and Theoretical Chemistry ,Fourier transform infrared spectroscopy ,Particle Size ,Metal-Organic Frameworks ,chemistry.chemical_classification ,Detection limit ,Aqueous solution ,Temperature ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,0210 nano-technology ,Powder Diffraction ,Nuclear chemistry - Abstract
In this work, we report a new hydrazine-functionalized Al(III)- based metal-organic framework having MIL-53 (MIL = Material of Institute Lavoisier) framework topology for the sensitive and selective detection of formaldehyde (FA). The phase purity of the thermally activated and as-synthesized forms of the material was examined by X-ray powder diffraction experiments, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The desolvated material (1') showed great potential for the selective sensing of FA in the existence of other potentially competitive aldehydes in both aqueous and 10 mM HEPES buffer (pH = 7.4) media. The fluorescence "turn-on" behavior of the reaction-based probe can be ascribed to the inhibition of the photoinduced electron transfer process (from the hydrazine group to the phenyl ring) because of the formation of the hydrazone moiety. The detection limit of the probe toward FA in HEPES buffer is 8.37 μM (0.25 ppm), which lies below the intracellular concentration of FA (100-400 μM). A very short response time (1 min) has been displayed by 1' for FA sensing. Moreover, a remarkable enhancement in the emission intensity (sevenfold and fourfold in aqueous and HEPES buffer media, respectively) of 1' was observed after 1 min of FA addition. Furthermore, the ability of the probe to detect FA in the vapor phase was demonstrated. Interestingly, the material is also capable to detect endogenous FA in cancer cells. All the above discussed features clearly reveal that the present material has a huge potential for selective recognition of FA in both real water and biological samples. more...
- Published
- 2018