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Start Over Author "Batista, Alzir A." Journal inorganic chemistry
18 results on '"Batista, Alzir A."'

1. “Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

Author

de Araujo-Neto, João Honorato, primary, Guedes, Adriana P. M., additional, Leite, Celisnolia M., additional, Moraes, Carlos André F., additional, Santos, Andressa L., additional, Brito, Rafaella da S., additional, Rocha, Thiago L., additional, Mello-Andrade, Francyelli, additional, Ellena, Javier, additional, and Batista, Alzir A., additional

Published
2023
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2. Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

Author

Leite, Celisnolia M., primary, Honorato, João, additional, Martin, Ana Carolina B. M., additional, Silveira, Rafael G., additional, Colombari, Felippe M., additional, Amaral, Jéssica C., additional, Costa, Analu R., additional, Cominetti, Márcia R., additional, Plutín, Ana M., additional, de Aguiar, Debora, additional, Vaz, Boniek G., additional, and Batista, Alzir A., additional

Published
2021
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3. Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo

Author

da Silva, Monize M., primary, Ribeiro, Gabriel H., additional, de Camargo, Mariana S., additional, Ferreira, Antônio G., additional, Ribeiro, Leandro, additional, Barbosa, Marília I. F., additional, Deflon, Victor M., additional, Castelli, Silvia, additional, Desideri, Alessandro, additional, Corrêa, Rodrigo S., additional, Ribeiro, Arthur B., additional, Nicolella, Heloiza D., additional, Ozelin, Saulo D., additional, Tavares, Denise C., additional, and Batista, Alzir A., additional

Published
2021
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4. Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction

Author

Ribeiro, Gabriel H., primary, Guedes, Adriana P. M., additional, de Oliveira, Tamires D., additional, de Correia, Camila R. S. T. b., additional, Colina-Vegas, Legna, additional, Lima, Mauro A., additional, Nóbrega, Joaquim A., additional, Cominetti, Márcia R., additional, Rocha, Fillipe V., additional, Ferreira, Antônio G., additional, Castellano, Eduardo E., additional, Teixeira, Felipe R., additional, and Batista, Alzir A., additional

Published
2020
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7. Remarkable Electronic Effect on the meso-Tetra(thienyl)porphyrins

Author

Leite, Taíse H. O., primary, Grawe, Gregory, additional, Honorato, João, additional, Cunha, Beatriz N., additional, Nascimento, Otaciro R., additional, de Vargas, Pamela S., additional, Donatoni, Carolina, additional, Oliveira, Kleber T., additional, Lopes, Jefferson M. S., additional, Barbosa Neto, Newton M., additional, Moreira, Wania C., additional, Dinelli, Luis R., additional, and Batista, Alzir A., additional

Published
2019
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10. Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria

Author

Oliveira, Geângela de Fátima Sousa, Gouveia, Florencio Sousa, Andrade, Alexandre Lopes, de Vasconcelos, Mayron Alves, Teixeira, Edson Holanda, Palmeira-Mello, Marcos V., Batista, Alzir A., Lopes, Luiz Gonzaga de França, de Carvalho, Idalina Maria Moreira, and Sousa, Eduardo Henrique Silva

Abstract

Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2′-bipyridine ligand conjugated to an anthracenyl moiety. These compounds coded GRBAand GRPAcontain 2,2′-bipyridine or 1,10-phenathroline as auxiliary ligands, respectively, which provide quite a distinct behavior. Notably, compound GRPAexhibited remarkably high photoproduction of singlet oxygen even in water (ϕΔ= 0.96), almost twice that of GRBA(ϕΔ= 0.52). On the other hand, this latter produced twice more superoxide and hydroxyl radical species than GRPA, which may be due to the modulation of their excited state. Interestingly, GRPAexhibited a modest binding to DNA (Kb= 4.51 × 104), while GRBAdid not show a measurable interaction only noticed by circular dichroism measurements. Studies with bacteria showed a great antimicrobial effect, including a synergistic effect in combination with commercial antibiotics. Besides that, GRBAshowed very low or no cytotoxicity against four mammalian cells, including a hard-to-treat MDA-MB-231, triple-negative human breast cancer. Potent activities were measured for GRBAupon blue light irradiation, where IC50of 43 and 13 nmol L–1were seen against hard-to-treat triple-negative human breast cancer (MDA-MB-231) and ovarian cancer cells (A2780), respectively. These promising results are an interesting case of a simple modification with expressive enhancement of biological activity that deserves further biological studies.

Published
2024
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11. Chiral Platinum(II) Complexes Featuring Phosphine and Chloroquine Ligands as Cytotoxic and Monofunctional DNA-Binding Agents

Author

Villarreal, Wilmer, primary, Colina-Vegas, Legna, additional, Rodrigues de Oliveira, Clayton, additional, Tenorio, Juan C., additional, Ellena, Javier, additional, Gozzo, Fábio C., additional, Cominetti, Marcia Regina, additional, Ferreira, Antonio G., additional, Ferreira, Marco Antonio Barbosa, additional, Navarro, Maribel, additional, and Batista, Alzir A., additional

Published
2015
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13. “Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitroand In VivoStudies

Author

de Araujo-Neto, João Honorato, Guedes, Adriana P. M., Leite, Celisnolia M., Moraes, Carlos André F., Santos, Andressa L., Brito, Rafaella da S., Rocha, Thiago L., Mello-Andrade, Francyelli, Ellena, Javier, and Batista, Alzir A.

Abstract

Upon exploration of the chemistry of the combination of ruthenium/arene with anthraquinone alizarin (L), three new complexes with the general formulas [Ru(L)Cl(η6-p-cymene)] (C1), [Ru(L)(η6-p-cymene)(PPh3)]PF6(C2), and [Ru(L)(η6-p-cymene)(PEt3)]PF6(C3) were synthesized and characterized using spectroscopic techniques (mass, IR, and 1D and 2D NMR), molar conductivity, elemental analysis, and X-ray diffraction. Complex C1exhibited fluorescence, such as free alizarin, while in C2and C3, the emission was probably quenched by monophosphines and the crystallographic data showed that hydrophobic interactions are predominant in intermolecular contacts. The cytotoxicity of the complexes was evaluated in the MDA-MB-231 (triple-negative breast cancer), MCF-7 (breast cancer), and A549 (lung) tumor cell lines and MCF-10A (breast) and MRC-5 (lung) nontumor cell lines. Complexes C1and C2were more selective to the breast tumor cell lines, and C2was the most cytotoxic (IC50= 6.5 μM for MDA-MB-231). In addition, compound C1performs a covalent interaction with DNA, while C2and C3present only weak interactions; however, internalization studies by flow cytometry and confocal microscopy showed that complex C1does not accumulate in viable MDA-MB-231 cells and is detected in the cytoplasm only after cell permeabilization. Investigations of the mechanism of action of the complexes indicate that C2promotes cell cycle arrest in the Sub-G1phase in MDA-MB-231, inhibits its colony formation, and has a possible antimetastatic action, impeding cell migration in the wound-healing experiment (13% of wound healing in 24 h). The in vivotoxicological experiments with zebrafish indicate that C1and C3exhibit the most zebrafish embryo developmental toxicity (inhibition of spontaneous movements and heartbeats), while C2, the most promising anticancer drug in the in vitropreclinical tests, revealed the lowest toxicity in in vivopreclinical screening.

Published
2023
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14. Synthesis and Characterization of [RuCl3(P-P)(H2O)] Complexes; P-P = Achiral or Chiral, Chelating Ditertiary Phosphine Ligands

Author

Dinelli, Luis R., primary, Batista, Alzir A., additional, Wohnrath, Karen, additional, de Araujo, Marcio P., additional, Queiroz, Salete L., additional, Bonfadini, Marcos R., additional, Oliva, Glaucius, additional, Nascimento, Otaciro R., additional, Cyr, Paul W., additional, MacFarlane, Kenneth S., additional, and James, Brian R., additional

Published
1999
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15. Synthesis, crystal structure, electrochemical, and spectroelectrochemical properties of the new manganese(III) complex [MnIII(BBPEN)][PF6] [H2BBPEN = N,N'-bis(2-hydroxybenzyl)-N,N'-bis(2-methylpyridyl)ethylenediamine]

Author

Neves, Ademir, primary, Erthal, Sueli M. D., additional, Vencato, Ivo, additional, Ceccato, Augusto S., additional, Mascarenhas, Yvonne P., additional, Nascimento, Otaciro R., additional, Horner, Manfredo, additional, and Batista, Alzir A., additional

Published
1992
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17. Synthesis and characterization of [RuCl3(P-P)(H20)] complexes; P-P=achiral or chiral, chelating....

Author

Dinelli, Luis R. and Batista, Alzir A.

Subjects
*RUTHENIUM compounds, *PHOSPHINE, *LIGANDS (Chemistry)
Abstract

Examines ruthenium complexes containing chelating ditertiary phosphine ligands. Reaction of the ruthenium complex with chlorine; X-ray crystallographic analysis of the complexes; Cyclic voltammetric measurements of the complexes; Effective precursors for catalytic asymmetric halogenation.

Published
1999
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18. Experimental and Theoretical DFT Study of Cu(I)/ N , N -Disubstituted- N '-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells.

Author

Leite CM, Honorato J, Martin ACBM, Silveira RG, Colombari FM, Amaral JC, Costa AR, Cominetti MR, Plutín AM, de Aguiar D, Vaz BG, and Batista AA

Abstract

Six complexes with the general formula [Cu(acylthioureato)(PPh 3 ) 2 ] were synthesized and characterized using spectroscopic techniques (IR, UV/visible, and 1D and 2D NMR), mass spectrometry, elemental analysis, and X-ray diffraction. Interpretation of the in vitro cytotoxicity data of Cu(I) complexes took into account their stability in cell culture medium. DFT calculations showed that NMR properties, such as the shielding of carbon atoms, are affected by relativistic effects, supported by the ZORA Hamiltonian in the theoretical calculations. Additionally, the calculation of the energies of the frontier molecular orbitals predicted that the structural changes of the acylthiourea ligands did not cause marked changes in the reactivity descriptors. All complexes were cytotoxic to the evaluated tumor cell lines [MDA-MB-231 (triple-negative breast cancer, TNBC), MCF-7 (breast cancer), and A549 (lung cancer)]. In the MDA-MB-231 cell line, complex 1 significantly altered the cytoskeleton of the cells, reducing the density and promoting the condensation of F-actin filaments. In addition, the compound caused an increase in the percentage of cells in the fragmented DNA region (sub-G0) and induced cell death via the apoptotic pathway starting at the IC 50 concentration. Taken together, the results show that complex 1 has cytotoxic and apoptotic effects on TNBC cells, which is a cell line originating from an aggressive, difficult-to-treat breast cancer.

Published
2022
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