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Four mixed-ligand complexes were prepared and formulated as [Ln(H2OBA)(H2PZDC)] and [Ln(H2OBA)(H2PDC)] {Ln = La & Gd; H2OBA = 4,4-oxybisbenzoic acid; H2PDC = 2,3-pyridinedicarboxylic acid; H2PZDC = 2,3-pyrazinedicarboxylic acid}. The complexes were modified by a nickel/cobalt impregnation method to generate bimetallic complexes 1–8. Fourier transform infrared (FTIR) spectroscopy analysis of the bimetallic complexes indicated that the carboxylate coordinated to the lanthanide ion via the OH- group while the Ni2+ and Co2+ ions were preferentially bonded to the nitrogen donor ligand via the N- group. Complete catalytic reduction of 4-nitrophenol to 4-aminophenol by the Ni@ complexes gave a maximum reduction time of 37 minutes for complex 1 while complex 7 gave a reduction time of 21 minutes. The rate constants were observed to increase with an increase in temperature up to 50 °C for complexes 3, 5, and 7. [ABSTRACT FROM AUTHOR]

Transition metal carboxylates with O- and N-donor ligands are interesting for their structural features. Seven novel isonicotinamide(inic)-based metal complexes of [Cd(inic)2(L1)2(H2O)2] · 2H2O (1) (L1 = 2-chloronicotinate), [Cd(inic)2(L2)2(H2O)2] (2) (L2 = 2,4-dichlorobenzoate), [Cu(inic)2(L3)2] (3) (L3 = 4-chlorophenoxyacetate), [Cu3(inic)6(L4)2(HL4)2(H2O)2] · 2H2O (4) (L4 = azelate), [Zn(inic)2(L1)2(H2O)2] · (inic) · H2O (5), [Zn(inic)(L5)(H2O)4] (6) (L5 = 3-nitrophthalate) and [Zn2(inic)2(L6)2] · 5H2O (7) (L6 = 1,4-cyclohexanedicarboxylate) have been obtained by the introduction of the carboxylates by the common solution method and are structurally featured by different techniques of EA, IR spectra, TG and SCXRD analysis. The X-ray studies told that these complexes display mononuclear to trinuclear structures with octahedral/square-pyramidal geometry around the Zn2+, trigonal bipyramidal/octahedral at the Cu2+ and octahedral for the Cd2+. The inic in 1–7 are coordinated only in monodentate fashion with its ring N, while 5 has the lattice inic. The carboxylates coordinated to the metal in monodentate, chelating bidentate and bridging bidentate fashions. The pair of complementary N-H···O H-bonds from the CONH2 of the inic were found in all compounds except 7. Except 1 and 2, all other compounds bear the CH-O contacts from the pyridine CH of the inic. The intricate intra- and intermolecular classical H-bonds, CH-N, CH-O, CH-Cl, CH2-O, O-N, O-O, Cl-O, Cl-Cl, CH-π, CH2-π, C-π, N-π, Cl-π and π-π associations are elucidated by the X-ray crystallographic studies, which push the discrete complexes into high-dimensional ordered supramolecular structures. [ABSTRACT FROM AUTHOR]

Two Co(II)-containing coordination polymers, {Co(TDC)(TPB)0.5·H2O}n (1) and {[Co2(2,6-NDC)2(TPB)]·MeCN·3H2O}n (2) (TPB = 1,2,4,5-tetra(4-pyridyl)benzene, H2TDC = 2,5-thiophenedicarboxylic acid, 2,6-H2NDC = 2,6-naphthalic acid), have been synthesized by a semi-rigid tetrapyridine ligand and auxiliary dicarboxylic ligands. The treatment ability of the compounds on skin necrosis after fracture was assessed and the related mechanism was discussed. First of all, the enzyme-linked immune sorbent assay (ELISA) detection kit was used in this research to detect the content level of the Recombinant Human Macrophage Colony stimulating Factor (MCSF) and Tumor Necrosis Factor-α (TNF-α) after compound treatment. Next, the real time quantitative polymerase chain reaction (RT-PCR) was conducted for the MMP2 and TIMP1 relative expression levels measurement. [ABSTRACT FROM AUTHOR]

By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H2O]8}n (1, H2ip = isophthalic acid and L = 1,1'-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]imidazole)) and {[Ni(L)(tdc)·2H2O]2}n (2, H2tdc = 2,5-thiophenedicarboxylic acid) have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction analyses, powder X-ray diffraction, thermogravimetric analysis and elemental analysis. In addition, in vitro anticancer activity of compounds 1 and 2 on four human ovarian cancer cells (CoC1, A2780, 3AO and OVCAR) was further determined. The results showed that compared with their organic ligands, the two compounds displayed efficient antitumor activity. [ABSTRACT FROM AUTHOR]

Two Cu(II)-based coordination polymers with the chemical formula of [Cu(bibb)(1,4-NDC)](DMF) (1, bibb = 1,4-bis(benzimidazol-1-yl)−2-butylene, 1,4-H2NDC = 1,4-naphthalenedicarboxylic acid, DMF = N,N-dimethylformamide) and [Cu(bibb)(1,4-NDC)](DMA) (2, N,N-dimethylacetamide) have been prepared. The structural solution and refinement results based on the crystal data show that complex 1 exhibits a rarely 2-fold interpenetrating 3D (4,5)-connected xah framework, and complex 2 possesses an unusual 3D (3,4)-connected dmc topology. Furthermore, the protective activity of compounds 1 and 2 on Viral myocarditis (VMC) was detected on CVB3-induced mouse viral myocarditis model. The relative expression of the inflammatory factors nf-κb and p38 in myocardial cells after compounds 1 and 2 treatment was measured with reverse transcription-polymerase chain reaction (RT-PCR). The release level of the inflammatory cytokines IL-1 and MCP-1 by myocardial cells was determined with enzyme linked immunosorbent assay (ELISA) detection kit. [ABSTRACT FROM AUTHOR]

A new Co(II)-based coordination polymer {[Co(ttpa)(1,4-bdc)]·H2O}n (1) as well as its nanoparticles (denoted as nano 1 hereafter) have been synthesized using hydrothermal and hand grinding methods (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,4-bdc = 1,4-benzenedicarboxylate). Furthermore, the protective effect of nano 1 on acute viral myocarditis mice was evaluated. Firstly, the CVB3-induced acute viral myocarditis model was successfully constructed and then nano 1 was given for indicated treatment. The in vivo activity of nano 1 was evaluated with mice survival rate and the CVB3 titer determination. The level of the inflammatory cytokines in the mice after treatment was measured with enzyme linked immunosorbent assay (ELISA) detection kit. [ABSTRACT FROM AUTHOR]

Solvothermal reactions of Co(OAc)2·4H2O or Ni(NO3)2·3H2O with 1,4-bis(benzimidazol-1-ylmethyl)-benzene (bmib) ligand and 1,4-terephthalic acid (H2bdc) afforded two 2-dimensional coordination polymers with the chemical formulae of [Co(bmib)(bdc)(H2O)2n (1) and [Ni(bmib)(bdc)(H2O)2n (2). Complexes 1 and 2 were characterized by elemental analysis and single-crystal X-ray diffraction. Furthermore, the anticancer activity of the complexes 1 and 2 was evaluated. Firstly, the CCK-8 assay was performed and MG63 osteogenic sarcoma cell proliferation was determined after complexes 1 and 2 treatment. Next, the Hoechst staining was performed to detect the morphological changes of treated MG63 cells. Subsequently, the western blot was conducted and the apoptotic related protein levels were determined. [ABSTRACT FROM AUTHOR]

A systematic investigation into the reactions of Cd(NO3)2·4H2O with o- and p-phenylenediacetic acid within the presence of the semi-rigid 1,4-bis(imidazol-1-ylmethyl)benzene (bimb) co-ligands under similar conditions was carried out. In this study, two novel coordination polymers containing Cd(II) ions as the metal ions {[Cd(μ-opda)(bimb)]·DMF}n (1, opda = 1,2-phenylenediacetate) and [Cd(μ-ppda)(bimb)0.5]n (2, ppda = 1,4-phenylenediacetate) have been prepared and structurally characterized. Furthermore, the inhibitory function of these two synthetic complexes on MG-63 human osteogenic sarcoma cells was evaluated with cell counting kit-8. And the Annexin V-FITC/PI apoptosis detection was performed to detect the induction ability of the complexes on the cancer cell apoptosis. Then, the western blot was performed to measure the activation level of the PTEN-AKT pathway. [ABSTRACT FROM AUTHOR]

In this study, two new mixed-ligand coordination polymers (CPs) {[Cd6(nbta)3(bimb)4(H2O)](H2O)3}n (1, bimb = 4,4′-bis((1H-imidazol-1-yl)methyl)−1,1′-biphenyl) and [Co3(bib)2(nbta)2]n (2, bib = 1,4-bis(benzimidazol-1-yl)−2-butene) have been successfully prepared by reaction of 5-nitro-1,2,3-benzenetricarboxylic acid (H3nbta) with different N-donor ligands under the solvothermal conditions. The as-prepared two CPs have been studied via the elemental analysis along with the single crystal X-ray diffraction. The inhibitory effect of synthesized new mixed-ligand coordination polymers on K562 leukemia cells was evaluated by CCK-8 assay. And the percentage of apoptotic cells after CPs 1 and 2 treatment was assessed by Annexin V-FITC/PI assay. Finally the in vivo effect of CPs on tumor was conducted by tumor volume and mice weight measurement. [ABSTRACT FROM AUTHOR]

In the current study, two new coordination complexes with the chemical formulae of [Co(cbba)(bimb)](H2O) (1, H2cbba = 3-((3-carboxybenzyl)oxy)benzoic acid, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine) and {[Co(pdc)(bimb)](DMF)}n (2, H2pda = pyrazine-2,5-dicarboxylic acid) have been successfully prepared by reaction of the Co(NO3)2·6H2O with the bimb ligand in the presence of different carboxylate ligands (H2cbba for 1 and H2pda for 2). The as-prepared two complexes have been determined via the elemental analysis, single crystal X-ray diffraction along with the powder X-ray diffraction. In addition, the photocatalytic activity of complex 2 toward the degradation of methyl violet (MV) in simulated polluted water was explored. [ABSTRACT FROM AUTHOR]

Solvothermal reaction of 4,4′-bis(imidazol-1-yl)diphenyl ether (BIDPE) or 1,4-Bis(imidazole-1-ylmethyl)benzene (BiB) with 1,4-benzenedicarboxylic acid (H2bdc) or 4,4'-(thiobis(methylene))dibenzoic acid (H2tba) in the presence of Zn(NO3)2·6H2O or Co(NO3)2·6H2O in a mixed solvent of H2O/DMF yielded two new coordination polymers, namely, [Zn(bdc)(BIDPE)](DMF)2(H2O) (1) and [Co(tba)(BIB)](H2tba)(DMF)(H2O)2 (2). These complexes were characterized by elemental analysis and X-ray single-crystal diffraction, which revealed that complex 1 is a 2D layered network with hexagonal windows while complex 2 is a 1D chain-like structure containing the 0D Co2(BIB)2 loops. Furthermore, the anticancer activity of the two coordination complexes has been evaluated via the CCK-8 assay and western blot assay. [ABSTRACT FROM AUTHOR]

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)0.5(oba)·DMF]·DMF·H2O} (1, L1 = N,N′-bis(4-pyridylmethyl)-naphthalene diimide, H2oba = 4,4′-oxydibenzoic acid) and [Co(L2)0.5(OBA)]n (2, L2 = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H2oba with different flexible N-donor organic ligands in the presence of Co(NO3)2·6H2O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg. [ABSTRACT FROM AUTHOR]

Two new transition metal-based coordination polymers [Zn3(bimb)2(nbta)2]n (1, bimb = 1,4-bis(imidazol-1-yl)-2-butene, H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid) and {[Cu3(nbta)2(bipp)2(H2O)2](H2O)2}n (2, bipp = 1,4-bis(pyridin-4-ylmethyl)piperazine) have been successfully prepared by reaction of 5-nitro-1,2,3-benzenetricarboxylic acid with the corresponding metal salts and the different N-donor ligands. Furthermore, the treatment effect of compounds 1 and 2 on nephrotic syndrome (NS) was evaluated and the specific mechanism was explored in this research. Firstly, to investigate the level of the Th17 cells and CD4 + CD25 + Foxp3+ regulate cells (Treg) in PBMC was detected with flow cytometry. The RT-PCR was performed to analyze the mRNA expression level of 16sRNA to determine the intestinal flora abundance. [ABSTRACT FROM AUTHOR]

In this study, we report the synthesis and structural characterization of two new Co(II) and Cu(II) containing coordination polymers {[Co2(btc)(mbtz)2]·7H2O}n (1), [Cu2(btc)(mbtz)2]n (2) by using the N donor ligand 1,3-bis(1H-1,2,4-triazol-1-ylmethyl)benzene (mbtz) and the O-donor ligand 1,2,4,5-benzenetetracarboxylic acid (H4btc) as the co-linkers. Furthermore, a sonochemical process was used to produce the nanostructures of coordination polymers 1 and 2. Then, we evaluated the anti-viability of nano 1 and 2 on LTEP lung cancer cells. And the Annexin V-FITC/PI staining was performed to detect the apoptosis induced by nano 1 and 2 on LTEP cells. The ROS level in LTEP cells was measured by DCFH-DA assay. [ABSTRACT FROM AUTHOR]