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• Posterior-inferior comminution dominantly increases superior-middle detached interfragmentary movement in VFNF, and results in varus deformation. • For VFNF with PICOM, alpha fixation performed optimally in patients with or without osteoporosis, due to the best anti-shear force, interfragmentary stability, lowest implant stress. • Although FNS is insufficient in resisting shear displacement, it took the advantages of greatest stiffness, anti-varus property and lowest bone yielding rate in osteoporosis cases, thus holds potential for further development in the treatment of femoral neck fractures with large-scale comminution or with osteoporosis. Fracture comminution occurs in 83.9%-94% of vertical femoral neck fractures (VFNFs), the majority of which were located in posterior-inferior region, and poses a clinical challenge in fixation stability. We conducted a subject-specific finite element analysis to determine the biomechanical features and optimal fixation selection for treating VFNF with posterior-inferior comminution. Eighteen models with three fracture types (VFNF without comminution [NCOM], with comminution [COM], with comminution + osteoporosis [COMOP]) and six internal fixation types (alpha [G-ALP], buttress [G-BUT], rhomboid [G-RHO], dynamic hip screw [G-DHS], invert triangle [G-ITR], femoral neck system (G-FNS)) were created based on the computed tomography data. By using the subject-specific finite element analysis method, stiffness, implant stress, yielding rate (YR) were compared. Additionally, in order to elucidate distinct biomechanical characters of different fracture types and fixation strategies, we calculated interfragmentary movement (IFM), detached interfragmentary movement (DIM), shear interfragmentary movement (SIM) of all fracture surface nodes. Generally, in comparison with NCOM, COM showed a 30.6% reduction of stiffness and 1.46-times higher mean interfragmentary movement. Besides, COM had a 4.66-times (p = 0.002) higher DIM at the superior-middle position, but similar SIM across fracture line, which presented as varus deformation. In COM and COMOP, among all six fixation strategies, G-ALP had significantly the lowest IFM (p <0.001) and SIM (p <0.001). Although G-FNS had significantly highest IFM and SIM (p <0.001), it had the highest stiffness and lowest DIM (p <0.001). In COMOP, YR was the lowest in G-FNS (2.67%). Posterior-inferior comminution primarily increases superior-middle detached interfragmentary movement in VFNF, which results in varus deformation. For comminuted VFNF with or without osteoporosis, alpha fixation has the best interfragmentary stability and anti-shear property among six current mainstream fixation strategies, but a relatively weaker stiffness and anti-varus property compared to fixed-angle devices. FNS is advantageous owing to stiffness, anti-varus property and bone yielding rate in osteoporosis cases, but is insufficient in anti-shear property. [ABSTRACT FROM AUTHOR]