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Your search keyword '"Zhang, Xiao‐di"' showing total 7 results
Start Over Author "Zhang, Xiao‐di" Journal inhalation toxicology
7 results on '"Zhang, Xiao‐di"'

6. Apoptosis of ATII Cells in Mice Induced by Phosgene

Author

Li, Wen-li, primary, Hai, Chun-xu, additional, Liang, Xin, additional, Zhang, Xiao-di, additional, Chen, Hong-li, additional, Qin, Xu-jun, additional, Liu, Riu, additional, He, Wei, additional, Wang, Peng, additional, and Li, Bo, additional

Published
2006
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7. Correlation between sPLA2-IIA and phosgene-induced rat acute lung injury.

Author

Chen HL, Hai CX, Liang X, Zhang XD, Liu R, and Qin XJ

Subjects
Animals, Blood Gas Analysis, Bronchoalveolar Lavage Fluid, Capillary Permeability drug effects, Group II Phospholipases A2 genetics, Interleukin-10 biosynthesis, Lung pathology, Lung Diseases pathology, Male, Organ Size, Oxygen blood, RNA, Messenger biosynthesis, RNA, Messenger genetics, Rats, Rats, Sprague-Dawley, Tumor Necrosis Factor-alpha biosynthesis, Chemical Warfare Agents toxicity, Group II Phospholipases A2 biosynthesis, Lung Diseases chemically induced, Lung Diseases enzymology, Phosgene toxicity
Abstract

Secreted phospholipase A(2) of group IIA (sPLA(2)-IIA) has been involved in a variety of inflammatory diseases, including acute lung injury. However, the specific role of sPLA(2)-IIA in phosgene-induced acute lung injury remains unidentified. The aim of the present study was to investigate the correlation between sPLA(2)-IIA activity and the severity of phosgene-induced acute lung injury. Adult male rats were randomly exposed to either normal room air (control group) or a concentration of 400 ppm phosgene (phosgene-exposed group) for there are 5 phosgene-exposed groups altogether. For the time points of 1, 3, 6, 12 and 24 h post-exposure, one phosgene-exposed group was sacrificed at each time point. The severity of acute lung injury was assessed by Pa(O2)/F(IO2) ratio, wet-to-dry lung-weight ratio, and bronchoalveolar lavage (BAL) fluid protein concentration. sPLA(2)-IIA activity in BAL fluid markedly increased between 1 h and 12 h after phosgene exposure, and reached its highest level at 6 h. Moreover, the trend of this elevation correlated well with the severity of lung injury. These results indicate that sPLA(2)-IIA probably participates in phosgene-induced acute lung injury.

Published
2009
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