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Ginkgo leaf disease poses a grave threat to Ginkgo biloba. The current management of Ginkgo leaf disease lacks precision guidance and intelligent technologies. To provide precision guidance for disease management and to evaluate the effectiveness of the implemented measures, the present study proposes a novel disease progression prediction (DPP) method for Ginkgo leaf blight with a multi-level feature translation architecture and enhanced spatiotemporal attention module (eSTA). The proposed DPP method is capable of capturing key spatiotemporal dependencies of disease symptoms at various feature levels. Experiments demonstrated that the DPP method achieves state-of-the-art prediction performance in disease progression prediction. Compared to the top-performing spatiotemporal predictive learning method (SimVP + TAU), our method significantly reduced the mean absolute error (MAE) by 19.95% and the mean square error (MSE) by 25.35%. Moreover, it achieved a higher structure similarity index measure (SSIM) of 0.970 and superior peak signal-to-noise ratio (PSNR) of 37.746 dB. The proposed method can accurately forecast the progression of Ginkgo leaf blight to a large extent, which is expected to provide valuable insights for precision and intelligent disease management. Additionally, this study presents a novel perspective for the extensive research on plant disease prediction. [ABSTRACT FROM AUTHOR]