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Please cite this paper as: Belshe et al. (2010). Efficacy of live attenuated influenza vaccine in children 6 months to 17 years of age. Influenza and Other Respiratory Viruses 4(3), 141–145. Background It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2–49 years of age. Objective To examine data from previously published pediatric studies to determine the efficacy of LAIV in various age groups. Methods Four studies in which the subject age range exceeded 36 months were identified: one 2-year study comparing LAIV with placebo and three 1-year studies comparing LAIV with trivalent inactivated influenza vaccine (TIV). Efficacy against any strain regardless of antigenic similarity to vaccine was analyzed by age; age groups were based on the study design and sample size. A logistic regression model was used to assess whether age, as a continuous variable, was an effect modifier on LAIV efficacy. Results The efficacy of LAIV did not vary with age in children aged 15–84 months compared with placebo or in children aged 6 months to 17 years compared with TIV. Conclusions The available data from prospective, randomized studies in children does not support the concept that prior repeated exposure to influenza, either through wild-type infection or vaccination with live, attenuated or inactivated vaccines, reduces the efficacy of LAIV compared with placebo or TIV. The decreased immunologic responses to LAIV reported in older individuals or those with pre-existing immunity do not appear to translate into reduced protection from influenza in children. [ABSTRACT FROM AUTHOR]

Please cite this paper as: Kim et al. (2012) Is abdominal obesity associated with the 2009 influenza A (H1N1) pandemic in Korean school-aged children? Influenza and Other Respiratory Viruses 6(5), 313-317. Objective Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. Methods This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. Results We found that H1N1 infection was associated with body mass index (BMI), waist circumference (WC), the use of facemasks, contact history with H1N1-infected persons, and overseas travel history ( P < 0·05). In addition, WC quartiles were significantly associated with H1N1 infection after adjusting for BMI and other confounding variables [OR (95% CI): 1·00, 1·10 (0·72-1·45), 1·13 (0·76-1·67), and 2·71 (1·74-4·24), respectively). Conclusions Abdominal obesity and the use of facemasks appear to be independently associated with H1N1 infection in school-aged children. We infer that providing education on wearing facemasks and specific planning for abdominally obese children and adolescents may be effective means of reducing the spread of the influenza pandemic in school-aged children. [ABSTRACT FROM AUTHOR]