1. Serum Uric Acid as a Diagnostic Biomarker for Rheumatoid Arthritis–Associated Interstitial Lung Disease
- Author
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Zitao Wang, Wen Wang, Ting Xiang, Bangdong Gong, and Jianmin Xie
- Subjects
Arthritis, Rheumatoid ,Interleukin-6 ,Transforming Growth Factor beta ,Immunology ,Humans ,Immunology and Allergy ,respiratory system ,Lung Diseases, Interstitial ,Biomarkers ,Interleukin-1 ,Uric Acid - Abstract
Previous studies have suggested a correlation between uric acid (UA) and lung lesion in some diseases. However, it remains unknown whether UA contributes to the lung injury in rheumatoid arthritis (RA). Our study aimed to investigate the clinical value of the UA level in the severity of rheumatoid arthritis–associated interstitial lung disease (RA-ILD). We measured UA in serum and bronchoalveolar lavage fluid (BALF), and UA levels of subjects were compared. As for the role of UA on ILD, we incubated A549 cells with UA and the expression of EMT markers was measured by immunofluorescence staining. The concentrations and messenger RNA expression of IL-1, IL-6, and transforming growth factor-β (TGF-β) were measured by ELISA and RT-PCR, respectively. We observed that serum UA levels in RA were significantly higher than those in controls. And, higher UA was measured in both serum and BALF of patients with RA-ILD, particularly those with interstitial pneumonia (UIP) pattern. Additionally, the correlation of the serum and BALF UA levels with serum KL-6, a biomarker of ILDs, in RA was significant (r = 0.44, p r = 0.43, p r = −0.61, p r = −0.34, p r = −0.43, p r = −0.30, p p p
- Published
- 2022