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Start Over Author "Nori, Priya" Journal infection control and hospital epidemiology
10 results on '"Nori, Priya"'

8. Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge.

Author

Nori P, Cowman K, Chen V, Bartash R, Szymczak W, Madaline T, Punjabi Katiyar C, Jain R, Aldrich M, Weston G, Gialanella P, Corpuz M, Gendlina I, and Guo Y

Subjects
Central Venous Catheters microbiology, Central Venous Catheters statistics & numerical data, Drug Resistance, Bacterial, Female, Humans, Male, Microbiological Techniques methods, Microbiological Techniques statistics & numerical data, Middle Aged, New York epidemiology, Outcome and Process Assessment, Health Care, Respiration, Artificial statistics & numerical data, Severity of Illness Index, Anti-Bacterial Agents therapeutic use, Bacteremia diagnosis, Bacteremia epidemiology, Bacteremia therapy, COVID-19 epidemiology, COVID-19 microbiology, COVID-19 therapy, Coinfection epidemiology, Coinfection microbiology, Coinfection virology, Mycoses diagnosis, Mycoses epidemiology, Mycoses therapy, SARS-CoV-2 isolation & purification
Abstract

We observed bacterial or fungal coinfections in COVID-19 patients admitted between March 1 and April 18, 2020 (152 of 4,267, 3.6%). Among these patients, mortality was 57%; 74% were intubated; 51% with bacteremia had central venous catheters. Time to culture positivity was 6-7 days, and 79% had received prior antibiotics. Metallo-β-lactamase-producing E. cloacae coinfections occurred in 5 patients.

Published
2021
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10. Screening of Clostridioides difficile carriers in an urban academic medical center: Understanding implications of disease.

Author

Baron SW, Ostrowsky BE, Nori P, Drory DY, Levi MH, Szymczak WA, Rinke ML, and Southern WN

Subjects
Academic Medical Centers, Adult, Aged, Aged, 80 and over, Carrier State diagnosis, Feces microbiology, Female, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Middle Aged, New York epidemiology, Polymerase Chain Reaction, Prevalence, Proportional Hazards Models, Prospective Studies, Young Adult, Carrier State epidemiology, Clostridioides difficile isolation & purification, Clostridium Infections diagnosis, Clostridium Infections epidemiology
Abstract

Objective: Efforts to reduce Clostridioides difficile infection (CDI) have targeted transmission from patients with symptomatic C. difficile. However, many patients with the C. difficile organism are carriers without symptoms who may serve as reservoirs for spread of infection and may be at risk for progression to symptomatic C. difficile. To estimate the prevalence of C. difficile carriage and determine the risk and speed of progression to symptomatic C. difficile among carriers, we established a pilot screening program in a large urban hospital., Design: Prospective cohort study., Setting: An 800-bed, tertiary-care, academic medical center in the Bronx, New York., Participants: A sample of admitted adults without diarrhea, with oversampling of nursing facility patients., Methods: Perirectal swabs were tested by polymerase chain reaction for C. difficile within 24 hours of admission, and patients were followed for progression to symptomatic C. difficile. Development of symptomatic C. difficile was compared among C. difficile carriers and noncarriers using a Cox proportional hazards model., Results: Of the 220 subjects, 21 (9.6%) were C. difficile carriers, including 10.2% of the nursing facility residents and 7.7% of the community residents (P = .60). Among the 21 C. difficile carriers, 8 (38.1%) progressed to symptomatic C. difficile, but only 4 (2.0%) of the 199 noncarriers progressed to symptomatic C. difficile (hazard ratio, 23.9; 95% CI, 7.2-79.6; P < .0001)., Conclusions: Asymptomatic carriage of C. difficile is prevalent among admitted patients and confers a significant risk of progression to symptomatic CDI. Screening for asymptomatic carriers may represent an opportunity to reduce CDI.

Published
2020
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