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Your search keyword '"Jacobs, Muazzam"' showing total 5 results
Start Over Author "Jacobs, Muazzam" Journal infection and immunity
5 results on '"Jacobs, Muazzam"'

1. Neurons Are Host Cells for Mycobacterium tuberculosis

Author

Randall, Philippa J., primary, Hsu, Nai-Jen, additional, Lang, Dirk, additional, Cooper, Susan, additional, Sebesho, Boipelo, additional, Allie, Nasiema, additional, Keeton, Roanne, additional, Francisco, Ngiambudulu M., additional, Salie, Sumayah, additional, Labuschagné, Antoinette, additional, Quesniaux, Valerie, additional, Ryffel, Bernhard, additional, Kellaway, Lauriston, additional, and Jacobs, Muazzam, additional

Published
2014
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3. Reduced Local Growth and Spread but Preserved Pathogenicity of a Δ purC Mycobacterium tuberculosis Auxotrophic Mutant in Gamma Interferon Receptor-Deficient Mice after Aerosol Infection

Author

Brown, Najmeeyah, primary, Jacobs, Muazzam, additional, Parida, Shreemanta K., additional, Botha, Tania, additional, Santos, Aldina, additional, Fick, Lizette, additional, Gicquel, Brigitte, additional, Jackson, Mary, additional, Quesniaux, Valerie, additional, and Ryffel, Bernhard, additional

Published
2005
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4. Reduced Local Growth and Spread but Preserved Pathogenicity of a ΔpurC Mycobacterium tuberculosisAuxotrophic Mutant in Gamma Interferon Receptor-Deficient Mice after Aerosol Infection

Author

Brown, Najmeeyah, Jacobs, Muazzam, Parida, Shreemanta K., Botha, Tania, Santos, Aldina, Fick, Lizette, Gicquel, Brigitte, Jackson, Mary, Quesniaux, Valerie, and Ryffel, Bernhard

Abstract

ABSTRACTWe compared the growth levels and pathogenicities of the Mycobacterium tuberculosisMT103 clinical strain with those of the ΔpurCmutant strain MYC1551, which is auxotrophic for purine in wild-type and gamma interferon receptor (IFN-γR)-deficient mice. The ΔpurCstrain MYC1551 grew initially in both wild-type and IFN-γR-deficient mice upon aerosol infection, but it grew much less than strain MT103 did. Despite the comparable bacterial burdens of the mice, IFN-γR-deficient mice succumbed to infection with ΔpurCstrain MYC1551 from necrotic pneumonia within 6 weeks of those infected with MT103. In conclusion, the ΔpurCmutant MYC1551 displays reduced growth but retains pathogenicity. Therefore, the use of mutant strains of M. tuberculosisas live vaccines may not be recommended.

Published
2005
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5. Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection.

Author

Brown N, Jacobs M, Parida SK, Botha T, Santos A, Fick L, Gicquel B, Jackson M, Quesniaux V, and Ryffel B

Subjects
Acute Disease, Animals, Mice, Mycobacterium tuberculosis pathogenicity, Nitric Oxide Synthase analysis, Nitric Oxide Synthase Type II, Pneumonia, Bacterial etiology, Signal Transduction, Interferon gamma Receptor, Mycobacterium tuberculosis growth & development, Receptors, Interferon physiology, Tuberculosis microbiology
Abstract

We compared the growth levels and pathogenicities of the Mycobacterium tuberculosis MT103 clinical strain with those of the DeltapurC mutant strain MYC1551, which is auxotrophic for purine in wild-type and gamma interferon receptor (IFN-gammaR)-deficient mice. The DeltapurC strain MYC1551 grew initially in both wild-type and IFN-gammaR-deficient mice upon aerosol infection, but it grew much less than strain MT103 did. Despite the comparable bacterial burdens of the mice, IFN-gammaR-deficient mice succumbed to infection with DeltapurC strain MYC1551 from necrotic pneumonia within 6 weeks of those infected with MT103. In conclusion, the DeltapurC mutant MYC1551 displays reduced growth but retains pathogenicity. Therefore, the use of mutant strains of M. tuberculosis as live vaccines may not be recommended.

Published
2005
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