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Start Over Author "IMAMURA, Daisuke" Journal infection and immunity
2 results on '"IMAMURA, Daisuke"'

1. A Point Mutation in carR Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription

Author

Samanta, Prosenjit, primary, Mandal, Rahul Shubhra, additional, Saha, Rudra Narayan, additional, Shaw, Sreeja, additional, Ghosh, Priyanka, additional, Dutta, Shanta, additional, Ghosh, Amit, additional, Imamura, Daisuke, additional, Morita, Masatomo, additional, Ohnishi, Makoto, additional, Ramamurthy, Thandavarayan, additional, and Mukhopadhyay, Asish Kumar, additional

Published
2020
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2. A Point Mutation in carRIs Involved in the Emergence of Polymyxin B-Sensitive Vibrio choleraeO1 El Tor Biotype by Influencing Gene Transcription

Author

Samanta, Prosenjit, Mandal, Rahul Shubhra, Saha, Rudra Narayan, Shaw, Sreeja, Ghosh, Priyanka, Dutta, Shanta, Ghosh, Amit, Imamura, Daisuke, Morita, Masatomo, Ohnishi, Makoto, Ramamurthy, Thandavarayan, and Mukhopadhyay, Asish Kumar

Abstract

Antimicrobial peptides play an important role in host defense against Vibrio cholerae. Generally, the V. choleraeO1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strains has been reported in recent years, including in the devastating Yemen cholera outbreak during 2016-2018. To investigate the factor(s) responsible for the shift in the trend of sensitivity to PB, we studied the two-component system encoded by carRS, regulating the lipid A modification of El Tor vibrios, and found that only carRcontains a single nucleotide polymorphism (SNP) in recently emerged PB-sensitive strains.

Published
2020
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