1. Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women.
- Author
-
Rogerson SJ, Beeson JG, Mhango CG, Dzinjalamala FK, and Molyneux ME
- Subjects
- Animals, Child, Female, Humans, In Vitro Techniques, Malaria, Falciparum blood, Placenta blood supply, Placenta parasitology, Plasmodium falciparum isolation & purification, Pregnancy, Pregnancy Complications, Parasitic parasitology, Malaria, Falciparum complications, Malaria, Falciparum immunology, Plasmodium falciparum immunology, Plasmodium falciparum pathogenicity, Pregnancy Complications, Parasitic blood, Pregnancy Complications, Parasitic immunology, Rosette Formation
- Abstract
We examined the formation of Plasmodium falciparum erythrocyte rosettes using parasite isolates from placental or peripheral blood of pregnant Malawian women and from peripheral blood of children. Five of 23 placental isolates, 23 of 38 maternal peripheral isolates, and 136 of 139 child peripheral isolates formed rosettes. Placental isolates formed fewer rosettes than maternal isolates (range, 0 to 7. 5% versus 0 to 33.5%; P = 0.002), and both formed fewer rosettes than isolates cultured from children (range, 0 to 56%; P < 0.0001). Rosette formation is common in infections of children but uncommon in pregnancy and rarely detected in placental isolates.
- Published
- 2000
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