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Na Lei,1,&ast; Bi-Xi Li,2,&ast; Kai-Fen Zhang,3 Hui Bao,4 Jian Ding,1 Yan Wang1 1Department of Disinfection and Supply, General Hospital of Central Theater Command of the People’s Liberation Army, Wuhan, People’s Republic of China; 2Department of Anesthesiology, General Hospital of Central Theater Command of the People’s Liberation Army, Wuhan, People’s Republic of China; 3Department of Outpatient, General Hospital of Central Theater Command of the People’s Liberation Army, Wuhan, People’s Republic of China; 4Department of Urology, General Hospital of Central Theater Command of the People’s Liberation Army, Wuhan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jian Ding; Yan Wang, Department of Disinfection and Supply, General Hospital of Central Theater Command of the People’s Liberation Army, 627&num;, Wuluo Road, Wuchang District, Wuhan, 430070, People’s Republic of China, Tel +86-18971123442, Fax +86-27-50772953, Email zbzqzyydj1995@163.com; whwangy1963@126.comObjective: To analyze the impact of the new supervision and management methods of infection controllers on the protection of third-party personnel entering and leaving Shanghai Fangcang shelter hospital, to provide a reference for the management of third-party personnel in Fangcang shelter hospitals.Methods: A total of 200 third-party personnel received with traditional supervision and management methods, and 156 received new supervision and management methods from the Fangcang shelter hospital of the Shanghai International Convention and Exhibition Center. The sociodemographic characteristics of third-party personnel, including gender, age, education level, work experience in fighting the epidemic with safety awareness, was analyzed. The effects of the two different management modes on the protection of third-party personnel were statistically analyzed by the Chi-square test or logistic regression analysis.Results: There were statistically significant differences in the incidence of infection among third-party personnel in terms of age, education level, work experience in fighting the epidemic in traditional supervision and management group, and whether they accepted the new supervision and management model had statistically significant differences (p < 0.05). The main causes of incorrect put on and take off protective clothing, such as wrong way to detach the face screen, wrong way to remove goggles, wrong way to undress protective clothing, wrong way to take off the shoe cover, hand washing steps omitted, are that causes infection of third-party personnel (p < 0.05).Conclusion: The new supervision and management model can reduce the infection rate of third-party personnel in Fangcang shelter hospitals through planned and purposeful training in terms of different age groups, education levels, work experience, and acceptance of protection knowledge.Keywords: shelter hospital, third-party personnel, new supervision, infection rate, Fangcang hospital