1. Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy
- Author
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Luzzago, Camilla, Ebranati, Erika, Sassera, Davide, Lo Presti, Alessandra, Lauzi, Stefania, Gabanelli, Elena, Ciccozzi, Massimo, and Zehender, Gianguglielmo
- Subjects
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BOVINE viral diarrhea virus , *GENETIC transduction , *PHYLOGENY , *BIOLOGICAL evolution , *POPULATION genetics ,CATTLE disease genetics ,REPRODUCTIVE isolation - Abstract
Abstract: Bovine viral diarrhea virus (BVDV) is a widespread and economically important pathogen of cattle; genetic typing of BVDV isolates distinguished two species, namely BVDV-1 and BVDV-2. BVDV-1 is the most widespread worldwide and it includes at least 11 subtypes. With the aim of clarifying the routes of circulation of BVDV-1 subtypes in an endemic area and in order to investigate the relationships between the genetic diversity of BVDV and its geographic distribution, a phylogenetic analysis of 5′ untranslated region of Italian sequences was performed using a new Bayesian framework allowing the spatial–temporal reconstruction of the evolutionary dynamics of highly variable viruses. Our analyses suggested that different BVDV subtypes entered the North-Eastern part of Italy at different times within a time span between 23 and 7years ago. The largest virus dispersion occurred between the mid 1990s and the early 2000s. A possible gravity-like dynamic of the infection, originating in larger animal population then following patterns of national commercial-flow, should be hypothesized. [Copyright &y& Elsevier]
- Published
- 2012
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