1. Production and physico-chemical characterization of nanocapsules of the essential oil from Lippia sidoides Cham
- Author
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Rita de Cássia Alves Pereira, Kirley Marques Canuto, Tigressa Helena Soares Rodrigues, Henriette M.C. Azeredo, Lorena Mara A. Silva, Celli Rodrigues Muniz, Edy Sousa de Brito, Carlos Alberto Caceres, and Náyra de Oliveira Frederico Pinto
- Subjects
Dispersity ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Nanocapsules ,0104 chemical sciences ,law.invention ,Thermogravimetry ,chemistry.chemical_compound ,Differential scanning calorimetry ,Pulmonary surfactant ,chemistry ,law ,Polycaprolactone ,0210 nano-technology ,Agronomy and Crop Science ,Thymol ,Essential oil ,Nuclear chemistry - Abstract
Lippia sidoides (Verbenaceae) is a medicinal plant from Northeastern Brazil, whose essential oil is rich in thymol, being a well-known antimicrobial phenol compound. The aim of this study was to produce suspensions of polycaprolactone (PCL)-coated nanocapsules incorporated with the essential oil from the L. sidoides leaves (EOLS) by the emulsion-diffusion method. EOLS nanocapsules were prepared by mixing EOLS and PCL with Kolliphor P 188® as the surfactant and ethyl laurate (core oil), all of them in varying concentrations (1, 2.5 and 5%). The said nanoformulations were assessed for their particle size and encapsulation efficiency (EE). The best condition was achieved with the nanoformulation containing 1% Kolliphor P 188®, 2.5% polycaprolactone, 2.5% EOLS and 5% ethyl laurate, emulsified at 10,000 rpm for 5 min, which presented an average particle diameter with 173.6 nm, a polydispersity index of 0.2 and an EE of 70.6%. Additionally, the nanoemulsion was characterized by the nuclear magnetic resonance (1H and diffusion-ordered NMR spectroscopy- DOSY), scanning electron microscopy, thermogravimetry and the differential scanning calorimetry. Furthermore, the suspension of nanocapsules of the EOLS was demonstrated to be stable at 5 °C during 60 days of storage in an accelerated stability study.
- Published
- 2016