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3 results on '"Madhu Emmadi"'

1. First Synthesis of the alpha-L-Serine Linked Consensus Disaccharide of Neisseria gonorrhoeae and Neisseria meningitidis

Author

Madhu Emmadi, Suvarn S. Kulkarni, and Santanu Jana

Subjects
Glycosylation, Disaccharide, Rare-Sugar, Shigella-Dysenteriae, L serine, Inner-Core Region, Meningococcal Disease, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Bioorganic Chemistry, Vaccine Development, medicine, Bioorganic chemistry, biology, Bacteria, Chemistry, Neisseria meningitidis, Bacterial, Total synthesis, Pilin, General Chemistry, biology.organism_classification, Yield (chemistry), Neisseria gonorrhoeae, Sugar Building-Blocks, Pathogens, Synthetic Methods, Derivatives
Abstract

The first total synthesis of the alpha-L-serine linked consensus disaccharide of Neisseria gonorrhoeae and Neisseria meningitidis was carried out in six linear steps, with 20.6% overall yield.

Published
2015

2. Total synthesis of MECA-79

Author

Madhu Emmadi, Suvarn S. Kulkarni, and Archanamayee Behera

Subjects
Carbohydrate, Glycosylation, Stereochemistry, General Chemical Engineering, Tn antigen, Anticancer Vaccines, Total synthesis, Ligand, General Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, D-Glucosamine, chemistry.chemical_compound, Transformation (genetics), Sulfation, Glycopeptide Antigens, chemistry, Antigen, Building-Blocks, Thioglycosides, bacteria, L-Selectin, TF-antigen, Derivative (chemistry)
Abstract

The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of D-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79.

Published
2014

3. Total synthesis of the bacillosamine containing alpha-L-serine linked trisaccharide of Neisseria meningitidis

Author

Madhu Emmadi and Suvarn S. Kulkarni

Subjects
De-Novo Synthesis, Aminoacid Coupling, Stereochemistry, Molecular Conformation, Stereoselective Glycosylation, Rare-Sugar, L serine, Meningococcal Disease, Neisseria meningitidis, medicine.disease_cause, Biochemistry, Analytical Chemistry, Streptococcus-Pneumoniae, chemistry.chemical_compound, Serine, medicine, Trisaccharide, Intermolecular Aglycon Transfer, chemistry.chemical_classification, Bacillosamine, Neisseria Meningitides, Genetic-Characterization, Organic Chemistry, Nucleophilic Displacement Of Triflates, Total synthesis, Repeating Unit, Hexosamines, General Medicine, D-Fucosamine, chemistry, Rare Sugars, Sugar Building-Blocks, Glycosylation Conditions, Trisaccharides
Abstract

Total synthesis of the bacillosamine containing L-serine linked O-trisaccharide of Neisseria meningitidis is described. The synthesis entails installation of two consecutive alpha-linkages including the coupling of bacillosamine with L-serine derivative. (C) 2014 Elsevier Ltd. All rights reserved.

Published
2014

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