Nur Azida Mohd Nasir, Arman Zaharil Mat Saad, Nor Sa'adah Bachok, Ahmad Hazri Ab Rashid, Zanariah Ujang, Kartini Noorsal, Norimah Yusof, Kamaruddin Hashim, Fatimah Mohd Nor, Farrah-Hani Imran, Nazri Mohd Yusof, Mohd Ariff Sharifudin, and Ahmad Sukari Halim
Background This clinical trial aimed to evaluate the clinical efficacy of chitosan derivative hydrogel paste (CDHP) as a wound bed preparation for wounds with cavities. Methods This study enrolled 287 patients, with 143 patients randomized into the CDHP group (treatment) and 144 patients randomized into the commercial hydroactive gel (CHG) group (control). The granulation tissue, necrotic tissue, patient comfort, clinical signs, symptoms, and patient convenience during the application and removal of the dressing were assessed. Results The study was completed by 111 and 105 patients from the treatment and control groups, respectively. Both groups showed an increasing mean percentage of wound granulation over time when the initial wound size and comorbidity were adjusted (F(10,198) = 4.61; p