1. Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration
- Author
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Guanghua Mao, Weiwei Feng, Fang Li, Qian Li, Wei Wang, Xiangyang Wu, Ting Zhao, Liuqing Yang, Yao Chen, Yangyang Ding, and Yun Feng
- Subjects
Male ,inorganic chemicals ,0301 basic medicine ,Bioavailability ,Malates ,Administration, Oral ,Biological Availability ,chemistry.chemical_element ,Absorption (skin) ,Type 2 diabetes ,010501 environmental sciences ,01 natural sciences ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,Feces ,03 medical and health sciences ,Chromium ,Chlorides ,Pharmacokinetics ,Chromium Compounds ,Diabetes mellitus ,otorhinolaryngologic diseases ,medicine ,Animals ,Tissue Distribution ,Pharmacology (medical) ,pharmacokinetic ,Picolinic Acids ,0105 earth and related environmental sciences ,chromium malate ,Pharmacology ,technology, industry, and agriculture ,Area under the curve ,Type 2 Diabetes Mellitus ,chromium picolinate ,medicine.disease ,Rats ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,chemistry ,Metals ,Administration, Intravenous ,Female ,chromium ,Research Article ,Nuclear chemistry - Abstract
OBJECTIVES: In our preliminary study, chromium malate could decrease the blood glucose level in mice with diabetes and exhibits good benefits in treating glycometabolism and adipose metabolization obstacle in rats with type 2 diabetes. This study was aimed at assessing the pharmacokinetics and bioavailability of chromium malate and influence on trace metals absorption in rats. METHODS: BAPP 2.3 pharmacokinetic calculating program (China Pharmaceutical University Medicine Center) was used to calculate the pharmacokinetic parameters. Models of type 2 diabetic mellitus rats were applied to analyzed Ca, Mg, Fe, Cu, and Zn contents. RESULTS: The results showed that mean retention time (MRT) in chromium malate group was significantly prolonged and the area under the curve (AUC) and relative bioavailability of chromium malate (male) group were significant increase compared to chromium picolinate group. The serum Ca, Mg, Fe, Cu, and Zn contents in chromium malate (at doses of 15 and 20 μg Cr/kg bw) groups were significantly increased compared to control group, chromium trichloride group, and chromium picolinate group in type 2 diabetes mellitus rats. CONCLUSIONS: Those results indicated that chromium malate can significantly prolong MRT and increase AUC (male). Moreover, chromium malate is more effective at treating increased serum Ca, Mg, Fe, Cu, and Zn contents compared to chromium trichloride and chromium picolinate.
- Published
- 2018
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