1. Indian Childhood Cirrhosis--A Re-Evaluation Of Its Pathomorphologic Features And Their Significance In The Light Of Clinical Data And Natural History Of The Disease.
- Author
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Nayak, N. C., Visalakshi, S., Singh, M., Chawla, Veena, Chandra, R. K., and Ramalingaswami, V.
- Subjects
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CIRRHOSIS of the liver , *FATTY liver , *LIVER cells , *VIRAL hepatitis , *NUTRITION research - Abstract
Out of 200 children suffering from Indian childhood cirrhosis studied during a five-year period, histologic confirmation of the disease was available in 141. Two out of 2l siblings also had ICC. In a pair of the twins while one had ICC, the other had fatty change and focal necrosis in the liver. The disease appears to be universally fatal. The hepatic lesion essentially consists of severe and continuing parenchyma! injury, progressive interstitial fibrosis leading rapidly to architectural disorganization, inflammatory reaction and poor hepatocytic regeneration, Intracellular hyaline forms a prominent feature and is often of diagnostic and prognostic value. Initial lesion in the disease is unknown though the 2 cases available with us and one of the twins showed non-specific changes unlike viral hepatitis. Even the established lesion is different from hepatic alteration in viral hepatitis. There seems to be at present no definite clue to the etiopathogenesis of the disease. Many aspects of the disease point against a viral or nutritional etiology. The role of toxins is to be explored. The liver cells of children suffering from ICC fail in certain respects to attain maturity. This and the role of heredity, viruses and toxins needs further study. [ABSTRACT FROM AUTHOR]
- Published
- 2012