1. Association of microsatellite instability and chronic obstructive pulmonary disorder in isocyanate-exposed population of Bhopal
- Author
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Rashmi Bathri and Protiti Bose
- Subjects
microsatellite ,COPD ,education.field_of_study ,High prevalence ,Molecular screening ,Exposed Population ,business.industry ,Population ,Microsatellite instability ,Context (language use) ,genomic instability ,medicine.disease ,Bhopal gas tragedy ,chronic obstructive pulmonary disorder ,inter-(simple sequence repeat) ,Environmental health ,Genetics ,Medicine ,Original Article ,Smoking status ,business ,education ,Genetics (clinical) - Abstract
Context: Survivors of the Bhopal gas disaster still suffer from various respiratory ailments. We examined the effects of exposures among a cross-section of current residents suffering from COPD by ISSR-PCR. Aims: Molecular screening of the gas-affected population of Bhopal with COPD for microsatellite instability due to exposure of MIC. Settings and Design: The isocyanate-exposed population of Bhopal city suffering from chronic obstructive pulmonary disorder. Materials and Methods: Inter-(SSR) analysis was used to characterize microsatellite instability in 52 MIC victims of Bhopal, suffering from COPD using (CA) 8 RG and (CA) 8 R[Y-Q] primer. Statistical Analysis Used: Association analyses were performed using regression analysis. Results: The study on the MIC-affected population in Bhopal showed weak association between microsatellite instability and age (r = + 0.37); exposure distance from site (r = −0.44); and smoking status(r = + 0.12); while regression analysis of the above parameters displayed supporting evidence. Conclusions: The high prevalence of smoking coupled with aging and poor living habits threatens, to further increase COPD incidences among this population, highlighting the need for enhanced screening efforts.
- Published
- 2012
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