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Your search keyword '"Sunil Kumar Deshmukh"' showing total 1 results
Start Over Author "Sunil Kumar Deshmukh" Journal indian journal of experimental biology
1 results on '"Sunil Kumar Deshmukh"'

1. Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim.Udagawa

Author

Periyasamy, Giridharan, Shilpa Amit, Verekar, Amit, Khanna, P D, Mishra, and Sunil Kumar, Deshmukh

Subjects
Magnetic Resonance Spectroscopy, Ascomycota, Cell Line, Tumor, Humans, Antineoplastic Agents, Apoptosis, Benzopyrans, Spectrophotometry, Ultraviolet, Drug Screening Assays, Antitumor, Mass Spectrometry, Cell Proliferation, Chromatography, Liquid
Abstract

Biodiversity provides critical support for drug discovery. A significant proportion of drugs are derived, directly or indirectly, from biological sources. Through high throughput screening (HTS) and bioassay-guided isolation, bioactive compound sclerotiorin has been isolated from an endophytic fungus Cephalotheca faveolata. Sclerotiorin was found to be potent anti-proliferative against different cancer cells. In this study sclerotiorin has been found to induce apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells.

Published
2012

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