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Byssinosis is an occupational hazard for the workers exposed to cotton dust. In this study 616 cotton textile workers were studied; out of which 149 had byssinosis; 37 (24.7%) had grade-1/2, 78 (52.7%) grade-1, 25 (16.6%) grade-2 and 9 (6.0%) of grade-3 byssinosis. Majority of the byssinotics were of age group between 36-40 years and had developed disease after 16 years of exposure. Disease was more common among smokers and severe, in whom consumption was more than 15 cigarettes/bidis per day for more than 10 years. Ventilatory function tests were markedly abnormal compared with non-byssinotic. On clinical examination and laboratory investigation (specially eosinophilia) and, radiological investigation (x-ray chest) no positive finding was detected. The high prevalence rate of the disease in this study was apparently due to poor working conditions of the workers.