1. Clinical Outcomes of Radiotherapy for Stage 1 Glottic Carcinoma: Comparing Accelerated Hyperfractionation and Once-daily Fractionation.
- Author
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MASASHI ENDO, YUKIKO FUKUDA, KOHEI OKADA, KAZUNARI OGAWA, MICHIKO NAKAMURA, SATORU TAKAHASHI, ERI MURAKAMI, CHIAKI SHIBAYAMA, MASAHIRO KAWAHARA, KEIKO AKAHANE, RYUTARO ONAGA, TAKAFUMI NAGATOMO, TAKEHARU KANAZAWA, HIROSHI NISHINO, HARUSHI MORI, and KATSUYUKI SHIRAI
- Subjects
GLOTTIS cancer ,RADIOTHERAPY ,TREATMENT effectiveness ,PNEUMONIA ,MUCOSITIS - Abstract
Background/Aim: Accelerated hyperfractionation (AHF) is used in head and neck cancer to improve the local control (LC) rate, but reports of outcomes for early-stage GC are limited. The outcomes of radiotherapy (RT) for stage 1 glottic carcinoma (GC) were retrospectively analyzed, comparing AHF and once-daily fractionation (ODF) using 2.0-2.4 Gy. Patients and Methods: A total of 102 patients with stage 1 GC underwent RT alone between 2007 and 2021, with 43 in the AHF group and 59 in the ODF group. A p-value less than 0.05 was considered to indicate a significant difference. Results: The 5-year LC rate was 98% in the AHF group and 91% in the ODF group (p=0.19). During RT, significantly more patients in the AHF group required opioids due to mucositis than in the ODF group (74% vs. 25%, p<0.001), and the rate of aspiration pneumonia tended to be higher in the AHF group than in the ODF group (7% vs. 0%, p=0.072). Conclusion: There was no difference in the LC rate between AHF and ODF for stage 1 GC. Moreover, the AHF group required opioids at a higher rate and tended to have a higher risk of developing aspiration pneumonia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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