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A research study conducted at Anhui Medical University in Hefei, China, explores the use of lysosome-targeted aggregated nanoparticles (LTANP) for cancer treatment. By inducing lysosomal swelling and membrane permeabilization in cancer cells, the nanoparticles trigger immunogenic cell death and enhance antitumor immune responses. The study highlights the potential of engineered nanostructures in directly combating cancer and offers insights for advanced nanoparticle-based cancer treatments. The research has been peer-reviewed and provides valuable information on reversing the immunosuppressive tumor microenvironment for cancer immunotherapy. [Extracted from the article]

A recent study conducted at Nanjing Normal University in Jiangsu, China, has explored the use of photodynamic therapy (PDT) in immunotherapy. The researchers designed a photosensitizer (PS) with an efficient inter-system crossing (ISC) rate to enhance the production of reactive oxygen species (ROS) during PDT. The PS was found to accumulate in lysosomes and, when activated by near-infrared light, led to lysosome membrane permeabilization (LMP) and disrupted calcium homeostasis, resulting in lysosome-dependent cell death. The study also demonstrated the potential of this approach for photodynamic immunotherapy. This research provides valuable insights into the development of a superior NIR photosensitizer and a strategy to enhance photodynamic immunotherapy. [Extracted from the article]

A recent report discusses research on chronic lymphocytic leukemia (CLL) conducted at the University of Alberta. The study focuses on the use of lysosome-disrupting agents in combination with the drugs venetoclax and obinutuzumab to increase the apoptotic response in CLL cells. The researchers found that obinutuzumab induces lysosome membrane permeabilization and cathepsin D release in CLL cells, and inhibiting cathepsins reduced cell death. Additionally, the lysosomotropic agent siramesine, when combined with venetoclax, increased cell death through an increase in reactive oxygen species and cathepsin release. The study suggests that lysosome-targeting drugs could be an effective strategy to overcome drug resistance in CLL when used in combination with venetoclax. [Extracted from the article]

Researchers at Zhejiang University in China have conducted a study on the impact of protein corona and pegylation on the accumulation and efficacy of lysosome-disrupting lipid nanoparticles in Kras-mutated cancer. The study found that protein corona facilitated targeted delivery of the nanoparticles to Kras-mutated cancer cells, while pegylation hindered delivery and efficacy. The researchers also discovered that the nanoparticles sensitized immunosuppressive Kras-mutated cancers to anti-PD1 immunotherapy. These findings suggest that the context-dependent role of the protein corona should be considered when designing nanoparticle-based drug delivery systems, and that PEGylation may not be suitable for all cancer types. [Extracted from the article]

A recent study conducted at Nantong University in Jiangsu, China, has explored the potential of pyroptosis as a pathway for cancer immunotherapy. Pyroptosis is a form of programmed cell death that triggers an inflammatory response. The researchers developed a lysosome-targeted near-infrared (NIR) photoactivated superoxide radical generator that induces pyroptosis and antitumor immunity. This innovative approach selectively accumulates in lysosomes, disrupts their integrity, and activates gasdermin D-mediated pyroptosis, leading to the maturation of dendritic cells and T-cell-mediated immune activation. This study provides valuable insights into pyroptosis-mediated cancer immunotherapy. [Extracted from the article]

A new report from the University of California San Diego (UCSD) discusses the use of nanomedicines to trigger immunogenic cell death in tumors. The researchers have developed proton sponge nano-assemblies (PSNAs) that can rupture lysosomes and induce cell death. The PSNAs were optimized to have high fluorescence, positive surface charge density, and cell cytotoxicity. The study found that PSNAs can activate immune cells and potentially stimulate anticancer immunity. [Extracted from the article]

Researchers from Tongji University School of Medicine in Shanghai, China have conducted a study on the role of lysosome-associated genes (LSAGs) in lung adenocarcinoma (LUAD). They identified 18 LSAGs associated with prognosis and used three LSAGs (KCNE1, NPC2, and SFTPD) to develop a predictive signature for LUAD patients. The study found that low expression of KCNE1, NPC2, and SFTPD promotes lung cancer cell proliferation and invasion, as well as M2 macrophage polarization. These findings may provide new insights for customized immunotherapy in lung cancer treatment. [Extracted from the article]

A recent report from Shandong University in Qingdao, China discusses new findings on pyroptosis, a cellular process that weakens the effectiveness of tumor therapies. The researchers propose a new approach to cancer immunotherapy using biodegradable copper nanoparticles that cause lysosomal rupture, leading to the destruction of organelles and abnormal aggregation of copper ions in tumor cells. This process inhibits autophagy and induces cuproptosis and pyroptosis, ultimately activating the immune response and inhibiting tumor growth. The researchers suggest that this lysosomal rupture-mediated "Broken Window Effect" could be a promising strategy for enhancing tumor therapy. [Extracted from the article]

A recent study conducted by researchers at Capital Medical University in Beijing, China has explored the use of nanopharmaceuticals for chemotherapy and immunogenic cell death (ICD). The study focused on a ruthenium-based nanodrug called KS-Ru, which was designed to target tumors and induce ICD. The researchers found that KS-Ru was able to translocate to the nucleus, causing DNA damage and inducing ICD. Additionally, the nanodrug self-assembled into nanoflowers in lysosomes, leading to lysosomal swelling and cell apoptosis. This research provides valuable insights for the development of novel ruthenium-based nanoantitumor drugs. [Extracted from the article]

A recent report from Jiangnan University in Wuxi, People's Republic of China, discusses the development of a new delivery system for immunostimulatory CpG ODNs, which have potential in immunotherapy. The researchers synthesized yeast beta-glucan grafted glycogen (Gly-Glu) nanoparticles as carriers for CpG ODNs. These nanoparticles showed high loading efficiency and were able to specifically target macrophages, resulting in higher cellular uptake and immunostimulation. The study offers a promising approach for the precise delivery of CpG ODNs to macrophages, which could have implications for immunotherapy. [Extracted from the article]

Cytoplasmic Structures, Cytoplasmic Vesicles, Dendritic Cells, Health and Medicine, Immunology, Intracellular Space, Antigen-Presenting Cells, Lysosomes, Mononuclear Phagocyte System According to the news editors, the research concluded: "Lysosomes and lysosome-associated structures are also critically engaged in antigen presentation and cross-presentation processes, which are pivotal for the induction of antigen specific adaptive immune response. Keywords: Antigen-Presenting Cells; Cytoplasmic Structures; Cytoplasmic Vesicles; Dendritic Cells; Health and Medicine; Immunology; Intracellular Space; Lysosomes; Mononuclear Phagocyte System EN Antigen-Presenting Cells Cytoplasmic Structures Cytoplasmic Vesicles Dendritic Cells Health and Medicine Immunology Intracellular Space Lysosomes Mononuclear Phagocyte System 1705 1705 1 10/16/23 20231017 NES 231017 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Research findings on mononuclear phagocyte system are discussed in a new report. [Extracted from the article]

Keywords: Adenocarcinoma; Biomarkers; Cancer; Cytoplasmic Structures; Cytoplasmic Vesicles; Diagnostics and Screening; Genetics; Health and Medicine; Intracellular Space; Lung Cancer; Lung Diseases and Conditions; Lysosomes; Oncology; Prognostic Markers EN Adenocarcinoma Biomarkers Cancer Cytoplasmic Structures Cytoplasmic Vesicles Diagnostics and Screening Genetics Health and Medicine Intracellular Space Lung Cancer Lung Diseases and Conditions Lysosomes Oncology Prognostic Markers 1361 1361 1 09/19/23 20230919 NES 230919 2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators discuss new findings in lung cancer. According to the news editors, the research concluded: "Pathway enrichment analysis revealed that lysosomes were closely associated with glucose metabolism, amino acid metabolism, and the immune response in patients with LUAD. The news editors obtained a quote from the research from Ningbo University: "Recent studies demonstrated that lysosomal rupture is involved in cancer migration, progression, and immune microenvironment formation. [Extracted from the article]

Keywords: Biomarkers; Cancer; Cytoplasmic Structures; Cytoplasmic Vesicles; Diagnostics and Screening; Drug Candidates; Drug Development; Drugs and Therapies; Genetics; Head and Neck Cancer; Head and Neck Neoplasms; Health and Medicine; Intracellular Space; Lysosomes; Oncology EN Biomarkers Cancer Cytoplasmic Structures Cytoplasmic Vesicles Diagnostics and Screening Drug Candidates Drug Development Drugs and Therapies Genetics Head and Neck Cancer Head and Neck Neoplasms Health and Medicine Intracellular Space Lysosomes Oncology 570 570 1 08/28/23 20230829 NES 230829 2023 AUG 29 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- A new study on head and neck cancer is now available. Biomarkers, Cancer, Cytoplasmic Structures, Cytoplasmic Vesicles, Diagnostics and Screening, Drug Candidates, Drug Development, Drugs and Therapies, Genetics, Head and Neck Cancer, Head and Neck Neoplasms, Health and Medicine, Intracellular Space, Lysosomes, Oncology. [Extracted from the article]

Keywords: Cancer; Connective Tissue Cells; Cytoplasmic Structures; Cytoplasmic Vesicles; Drugs and Therapies; Health and Medicine; Immunology; Immunotherapy; Intracellular Space; Lysosomes; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Oncology; Phagocytes EN Cancer Connective Tissue Cells Cytoplasmic Structures Cytoplasmic Vesicles Drugs and Therapies Health and Medicine Immunology Immunotherapy Intracellular Space Lysosomes Macrophages Mononuclear Phagocyte System Myeloid Cells Oncology Phagocytes 511 511 1 08/21/23 20230822 NES 230822 2023 AUG 22 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Researchers detail new data in cancer. Different from traditional platinum-based antitumour drugs by inhibition of DNAs, we also deliver a strong antitumour strategy by targeting lysosome to induce divergent metabolic programs in macrophages and tumours for cancer immunotherapy.". [Extracted from the article]

Keywords: Adenocarcinoma; Cancer; Colon Cancer; Cytoplasmic Structures; Cytoplasmic Vesicles; Gastroenterology; Genetics; Health and Medicine; Intracellular Space; Lysosomes; Oncology EN Adenocarcinoma Cancer Colon Cancer Cytoplasmic Structures Cytoplasmic Vesicles Gastroenterology Genetics Health and Medicine Intracellular Space Lysosomes Oncology 286 286 1 05/08/23 20230509 NES 230509 2023 MAY 9 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Data detailed on colon cancer have been presented. The relationship between a single lysosome-related gene and cancer has previously been studied, but the relationship between the lysosome-related genes (LRGs) and colon adenocarcinoma (COAD) remains unknown.". [Extracted from the article]

Keywords for this news article include: Taichung, Taiwan, Asia, Angiotensin II Receptor Antagonist, Angiotensin Receptors, Angiotensins, Autacoids, Biological Factors, Cytoplasmic Granules, Cytoplasmic Structures, Cytoplasmic Vesicles, Cytoplasmic and Nuclear Receptors, DNA-Binding Proteins, Drugs and Therapies, G-Protein-Coupled Receptors, Health and Medicine, Immunotherapy, Intracellular Space, Membrane Proteins, Microbodies, Neuropeptide Receptors, Neuropeptides, Oligopeptides, Organelles, PPAR gamma, Peptide Hormones, Peptide Proteins, Peptide Receptors, Peptides, Peroxisome Proliferator-Activated Receptors, Peroxisomes, Proteins, Transcription Factors, Chung Shan Medical University Hospital. [Extracted from the article]

The chimeric protein construct of claim 36, the first target cell of interest comprising an immune effector cell, a cell that regulates an immune effector cell, a regulatory cell, a lymphoid cell, secretory cell, or a cell that inhibits or promotes cell death." The chimeric protein construct of claim 26, wherein the target cell of interest is an immune effector cell selected from the group consisting of a T-cell, a regulatory T (Treg) cell, a B-cell, a dendritic cell, or a natural killer (NK) cell. The chimeric protein construct of claim 25, the at least one antigen-binding domain of the CAR recognizing or binding to an antigen on an immune effector cell, a lymphoid cell, a cell that regulates an immune effector cell, a regulatory cell, a lymphoid cell, a secretory cell, or a cell that inhibits or promotes cell death. [Extracted from the article]

According to the news editors, the research concluded: "I highlight important and novel implications to CD8 T cell vaccines and immunotherapy." Keywords: New York City; State:New York; United States; North and Central America; Antigens; Biological Factors; Biological Products; CD Antigens; CD8 Antigens; Cytoplasmic Structures; Cytoplasmic Vesicles; Drugs and Therapies; Health and Medicine; Immunization; Immunology; Immunotherapy; Intracellular Space; Phagosomes; T-Lymphocyte Antigens; Vaccines EN New York City State:New York United States North and Central America Antigens Biological Factors Biological Products CD Antigens CD8 Antigens Cytoplasmic Structures Cytoplasmic Vesicles Drugs and Therapies Health and Medicine Immunization Immunology Immunotherapy Intracellular Space Phagosomes T-Lymphocyte Antigens Vaccines 569 569 1 03/23/23 20230320 NES 230320 2023 MAR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on Immunization - Vaccines. Within DCs, MHC-I are enriched within endosomal recycling compartments (ERC) and traffic to microbe-carrying phagosomes under the control of phagosome-compartmentalized TLR signals to favor CD8 T cell cross-priming to microbial antigens. [Extracted from the article]