1. Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer
- Author
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Lubos Petruzelka, Jan Spacek, Bohuslav Konopasek, Michal Vocka, and Eva Zavadova
- Subjects
Cellular immunity ,biology ,medicine.diagnostic_test ,business.industry ,CD3 ,Immunology ,medicine.disease ,CD19 ,Pleuran ,Flow cytometry ,chemistry.chemical_compound ,Breast cancer ,Immune system ,Oncology ,chemistry ,biology.protein ,medicine ,Cancer research ,Immunology and Allergy ,business ,CD8 - Abstract
Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I–II) in clinical and imaging remission. Methodology: Antitumor cellular immunity (CD19+, CD3+, CD4+ and CD8+ T lymphocytes and natural killer cells) of 195 patients (49 in the pleuran group and 146 in the control group) was measured by flow cytometry. Results: We observed a significant increase in the absolute number of CD3+, CD19+, CD4+ and CD8+ T lymphocytes in the pleuran group compared with the control group. Conclusion: Our results suggest potential benefit of continuous pleuran administration on immune rehabilitation of cellular antitumor immunity and better prognosis in breast cancer patients in remission.
- Published
- 2022