1. Do heat shock proteins control the balance of T-cell regulation in inlammatory diseases?
- Author
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Willem van Eden, Alberta G. A. Paul, Marca H. M. Wauben, Ruurd van der Zee, Stephen M. Anderton, Berent J. Prakken, and Uwe Wendling
- Subjects
Inflammation ,Autoimmune disease ,endocrine system ,T-Lymphocytes ,T cell ,Immunology ,Peripheral tolerance ,Autoimmunity ,hemic and immune systems ,chemical and pharmacologic phenomena ,Disease ,Biology ,Lymphocyte Activation ,medicine.disease ,Immune system ,medicine.anatomical_structure ,Immunity ,Heat shock protein ,biological sciences ,medicine ,Humans ,Disease process ,Heat-Shock Proteins - Abstract
Heat shock proteins (Hsps) are remarkably immunogenic, despite their high degree of evolutionary conservation. Experimental and clinical observations on autoimmune diseases indicate that immune responses to Hsps arise spontaneously during the disease process. Based on current evidence, Willem van Eden and colleagues argue that such immunity to Hsps is part of a normal immunoregulatory T-cell response with disease controlling potential.
- Published
- 1998
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