12 results on '"McGovern, Naomi"'
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2. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2
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Sander, Jil, Schmidt, Susanne V., Cirovic, Branko, McGovern, Naomi, Papantonopoulou, Olympia, Hardt, Anna-Lena, Aschenbrenner, Anna C., Kreer, Christoph, Quast, Thomas, Xu, Alexander M., Schmidleithner, Lisa M., Theis, Heidi, Thi Huong, Lan Do, Sumatoh, Hermi Rizal Bin, Lauterbach, Mario A.R., Schulte-Schrepping, Jonas, Günther, Patrick, Xue, Jia, Baßler, Kevin, Ulas, Thomas, Klee, Kathrin, Katzmarski, Natalie, Herresthal, Stefanie, Krebs, Wolfgang, Martin, Bianca, Latz, Eicke, Händler, Kristian, Kraut, Michael, Kolanus, Waldemar, Beyer, Marc, Falk, Christine S., Wiegmann, Bettina, Burgdorf, Sven, Melosh, Nicholas A., Newell, Evan W., Ginhoux, Florent, Schlitzer, Andreas, and Schultze, Joachim L.
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- 2017
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3. Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages
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McGovern, Naomi, Schlitzer, Andreas, Gunawan, Merry, Jardine, Laura, Shin, Amanda, Poyner, Elizabeth, Green, Kile, Dickinson, Rachel, Wang, Xiao-nong, Low, Donovan, Best, Katie, Covins, Samuel, Milne, Paul, Pagan, Sarah, Aljefri, Khadija, Windebank, Martin, Saavedra, Diego Miranda, Larbi, Anis, Wasan, Pavandip Singh, Duan, Kaibo, Poidinger, Michael, Bigley, Venetia, Ginhoux, Florent, Collin, Matthew, and Haniffa, Muzlifah
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- 2014
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4. IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
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Schlitzer, Andreas, McGovern, Naomi, Teo, Pearline, Zelante, Teresa, Atarashi, Koji, Low, Donovan, Ho, Adrian W.S., See, Peter, Shin, Amanda, Wasan, Pavandip Singh, Hoeffel, Guillaume, Malleret, Benoit, Heiseke, Alexander, Chew, Samantha, Jardine, Laura, Purvis, Harriet A., Hilkens, Catharien M.U., Tam, John, Poidinger, Michael, Stanley, Richard E., Krug, Anne B., Renia, Laurent, Sivasankar, Baalasubramanian, Ng, Lai Guan, Collin, Matthew, Ricciardi-Castagnoli, Paola, Honda, Kenya, Haniffa, Muzlifah, and Ginhoux, Florent
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- 2013
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5. Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
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Haniffa, Muzlifah, Shin, Amanda, Bigley, Venetia, McGovern, Naomi, Teo, Pearline, See, Peter, Wasan, Pavandip Singh, Wang, Xiao-Nong, Malinarich, Frano, Malleret, Benoit, Larbi, Anis, Tan, Pearlie, Zhao, Helen, Poidinger, Michael, Pagan, Sarah, Cookson, Sharon, Dickinson, Rachel, Dimmick, Ian, Jarrett, Ruth F., Renia, Laurent, Tam, John, Song, Colin, Connolly, John, Chan, Jerry K.Y., Gehring, Adam, Bertoletti, Antonio, Collin, Matthew, and Ginhoux, Florent
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- 2012
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6. Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency
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Simoni, Yannick, primary, Fehlings, Michael, additional, Kløverpris, Henrik N., additional, McGovern, Naomi, additional, Koo, Si-Lin, additional, Loh, Chiew Yee, additional, Lim, Shawn, additional, Kurioka, Ayako, additional, Fergusson, Joannah R., additional, Tang, Choong-Leong, additional, Kam, Ming Hian, additional, Dennis, Koh, additional, Lim, Tony Kiat Hon, additional, Fui, Alexander Chung Yaw, additional, Hoong, Chan Weng, additional, Chan, Jerry Kok Yen, additional, Curotto de Lafaille, Maria, additional, Narayanan, Sriram, additional, Baig, Sonia, additional, Shabeer, Muhammad, additional, Toh, Sue-Anne Ee Shiow, additional, Tan, Henry Kun Kiaang, additional, Anicete, Rosslyn, additional, Tan, Eng-Huat, additional, Takano, Angela, additional, Klenerman, Paul, additional, Leslie, Alasdair, additional, Tan, Daniel S.W., additional, Tan, Iain Beehuat, additional, Ginhoux, Florent, additional, and Newell, Evan W., additional
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- 2018
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7. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
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Guilliams, Martin, primary, Dutertre, Charles-Antoine, additional, Scott, Charlotte L., additional, McGovern, Naomi, additional, Sichien, Dorine, additional, Chakarov, Svetoslav, additional, Van Gassen, Sofie, additional, Chen, Jinmiao, additional, Poidinger, Michael, additional, De Prijck, Sofie, additional, Tavernier, Simon J., additional, Low, Ivy, additional, Irac, Sergio Erdal, additional, Mattar, Citra Nurfarah, additional, Sumatoh, Hermi Rizal, additional, Low, Gillian Hui Ling, additional, Chung, Tam John Kit, additional, Chan, Dedrick Kok Hong, additional, Tan, Ker Kan, additional, Hon, Tony Lim Kiat, additional, Fossum, Even, additional, Bogen, Bjarne, additional, Choolani, Mahesh, additional, Chan, Jerry Kok Yen, additional, Larbi, Anis, additional, Luche, Hervé, additional, Henri, Sandrine, additional, Saeys, Yvan, additional, Newell, Evan William, additional, Lambrecht, Bart N., additional, Malissen, Bernard, additional, and Ginhoux, Florent, additional
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- 2016
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8. A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures
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Wong, Michael Thomas, primary, Ong, David Eng Hui, additional, Lim, Frances Sheau Huei, additional, Teng, Karen Wei Weng, additional, McGovern, Naomi, additional, Narayanan, Sriram, additional, Ho, Wen Qi, additional, Cerny, Daniela, additional, Tan, Henry Kun Kiaang, additional, Anicete, Rosslyn, additional, Tan, Bien Keem, additional, Lim, Tony Kiat Hon, additional, Chan, Chung Yip, additional, Cheow, Peng Chung, additional, Lee, Ser Yee, additional, Takano, Angela, additional, Tan, Eng-Huat, additional, Tam, John Kit Chung, additional, Tan, Ern Yu, additional, Chan, Jerry Kok Yen, additional, Fink, Katja, additional, Bertoletti, Antonio, additional, Ginhoux, Florent, additional, Curotto de Lafaille, Maria Alicia, additional, and Newell, Evan William, additional
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- 2016
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9. Population of Monocyte-Derived Macrophages
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McGovern, Naomi, primary, Schlitzer, Andreas, additional, Gunawan, Merry, additional, Jardine, Laura, additional, Shin, Amanda, additional, Poyner, Elizabeth, additional, Green, Kile, additional, Dickinson, Rachel, additional, Wang, Xiao-nong, additional, Low, Donovan, additional, Best, Katie, additional, Covins, Samuel, additional, Milne, Paul, additional, Pagan, Sarah, additional, Aljefri, Khadija, additional, Windebank, Martin, additional, Miranda-Saavedra, Diego, additional, Larbi, Anis, additional, Wasan, Pavandip Singh, additional, Kaibo, Duan, additional, Poidinger, Michael, additional, Bigley, Venetia, additional, Ginhoux, Florent, additional, Collin, Matthew, additional, and Haniffa, Muzlifah, additional
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- 2015
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10. Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages
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McGovern, Naomi, primary, Schlitzer, Andreas, additional, Gunawan, Merry, additional, Jardine, Laura, additional, Shin, Amanda, additional, Poyner, Elizabeth, additional, Green, Kile, additional, Dickinson, Rachel, additional, Wang, Xiao-nong, additional, Low, Donovan, additional, Best, Katie, additional, Covins, Samuel, additional, Milne, Paul, additional, Pagan, Sarah, additional, Aljefri, Khadija, additional, Windebank, Martin, additional, Miranda-Saavedra, Diego, additional, Larbi, Anis, additional, Wasan, Pavandip Singh, additional, Duan, Kaibo, additional, Poidinger, Michael, additional, Bigley, Venetia, additional, Ginhoux, Florent, additional, Collin, Matthew, additional, and Haniffa, Muzlifah, additional
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- 2014
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11. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
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Bjarne Bogen, Mahesh Choolani, Dedrick Kok Hong Chan, Tony Lim Kiat Hon, Charles-Antoine Dutertre, Jerry Kok Yen Chan, Florent Ginhoux, Anis Larbi, Sandrine Henri, Svetoslav Chakarov, Citra Nurfarah Zaini Mattar, Evan W. Newell, Naomi McGovern, Sofie Van Gassen, Jinmiao Chen, Simon Tavernier, Tam John Kit Chung, Michael Poidinger, Sergio Erdal Irac, Dorine Sichien, Hervé Luche, Ivy Low, Hermi Sumatoh, Sofie De Prijck, Gillian Low, Ker-Kan Tan, Bart N. Lambrecht, Even Fossum, Martin Guilliams, Yvan Saeys, Bernard Malissen, Charlotte L. Scott, Pulmonary Medicine, McGovern, Naomi [0000-0001-5200-2698], Apollo - University of Cambridge Repository, Department of Biomedical Molecular Biology [Ghent], Universiteit Gent = Ghent University (UGENT), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unit of Immunoregulation and Mucosal Immunology [Ghent, Belgium], VIB Inflammation Research Center [Ghent, Belgium], Program in Emerging Infectious Disease, Duke-NUS Medical School [Singapore], Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Department of Information Technology [Gent], Data Mining and Modeling for Biomedicine [Ghent, Belgium], Department of Internal Medicine [Ghent, Belgium], Experimental Fetal Medicine Group [Singapore], National University of Singapore (NUS)-Yong Loo Lin School of Medicine [Singapore], Department of Surgery [Singapore], Department of Pathology [Singapour], National University of Singapore (NUS), K.G. Jebsen Centre for Influenza Vaccine Research [Oslo, Norway], University of Oslo (UiO)-Oslo University Hospital [Oslo], Center for Immune Regulation [Oslo] (CIR), Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Rigshospitalet [Copenhagen], Copenhagen University Hospital-Copenhagen University Hospital, Department of Reproductive Medicine [Singapore], KK Women's and Children's Hospital [Singapore], Cancer and Stem Cell Biology Program [Singapore], Centre d'Immunophénomique (CIPHE), Department of Pulmonary Medicine [Rotterdam, The Netherlands], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Universiteit Gent, and HENRI, Sandrine
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EXPRESSION ,0301 basic medicine ,Resource ,STEADY-STATE ,HOMEOSTASIS ,BLOOD ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,BONE-MARROW ,Cellular differentiation ,Immunology ,Inflammation ,Computational biology ,Biology ,Macaque ,Flow cytometry ,03 medical and health sciences ,Mice ,0302 clinical medicine ,biology.animal ,medicine ,Immunology and Allergy ,Macrophage ,Animals ,Humans ,Mass cytometry ,MACROPHAGES ,SIGNALING CONTROLS ,LYMPH-NODES ,medicine.diagnostic_test ,Biology and Life Sciences ,hemic and immune systems ,Cell Differentiation ,Dendritic Cells ,Flow Cytometry ,CLONOGENIC PROGENITOR ,Mice, Inbred C57BL ,Protein Transport ,030104 developmental biology ,Infectious Diseases ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Macaca ,medicine.symptom ,Conventional Dendritic Cell ,Function (biology) ,RESPONSES ,030215 immunology - Abstract
Summary Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic potential. Multiple DC subsets have been described, and it remains challenging to align them across tissues and species to analyze their function in the absence of macrophage contamination. Here, we provide and validate a universal toolbox for the automated identification of DCs through unsupervised analysis of conventional flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues. The use of a minimal set of lineage-imprinted markers was sufficient to subdivide DCs into conventional type 1 (cDC1s), conventional type 2 (cDC2s), and plasmacytoid DCs (pDCs) across tissues and species. This way, a large number of additional markers can still be used to further characterize the heterogeneity of DCs across tissues and during inflammation. This framework represents the way forward to a universal, high-throughput, and standardized analysis of DC populations from mutant mice and human patients., Graphical Abstract Image 1, Highlights • A conserved gating strategy aligns dendritic cells (DCs) in mouse and human tissues • Unsupervised computational analysis of flow cytometry data outperforms manual analysis • Mass cytometry reveals heterogeneity of DC subsets across mouse and human tissues • DC activation upon inflammation tracked by automated analysis of mass cytometry, Using unsupervised analysis of flow cytometry and mass cytometry data obtained from multiple mouse, macaque, and human tissues, Guilliams et al. provide a universal toolbox for the automated identification of dendritic cells. This framework represents the way forward to high-throughput and standardized analysis of dendritic cells from mutant mice and patients.
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- 2016
12. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
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Koji Atarashi, Adrian W. S. Ho, Amanda Shin, Pavandip Singh Wasan, Benoit Malleret, Donovan Low, Laura Jardine, Anne Krug, Florent Ginhoux, Alexander F. Heiseke, Naomi McGovern, Andreas Schlitzer, E. Richard Stanley, Laurent Rénia, Paola Ricciardi-Castagnoli, Peter See, Lai Guan Ng, Matthew Collin, Kenya Honda, Muzlifah Haniffa, Guillaume Hoeffel, Catharien M. U. Hilkens, Harriet A. Purvis, Baalasubramanian Sivasankar, Pearline Teo, Samantha Chew, John Kit Chung Tam, Teresa Zelante, Michael Poidinger, McGovern, Naomi [0000-0001-5200-2698], and Apollo - University of Cambridge Repository
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IgG ,Cellular differentiation ,medicine.medical_treatment ,Immunology ,Respiratory Mucosa ,Biology ,Interleukin-23 ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Immune system ,Intestinal mucosa ,Receptors ,medicine ,T helper 17 cell ,Immunology and Allergy ,Animals ,Humans ,Antigens ,Intestinal Mucosa ,skin and connective tissue diseases ,CD24 ,030304 developmental biology ,0303 health sciences ,Lamina propria ,CD11b Antigen ,CD11b ,Aspergillus fumigatus ,Macrophages ,Interleukin-17 ,Receptors, IgG ,CD24 Antigen ,Cell Differentiation ,Dendritic Cells ,3. Good health ,Cell biology ,Antigens, CD11b ,Antigens, CD24 ,Interferon Regulatory Factors ,Th17 Cells ,fms-Like Tyrosine Kinase 3 ,Cytokine ,medicine.anatomical_structure ,Infectious Diseases ,Fms-Like Tyrosine Kinase 3 ,Conventional Dendritic Cell ,030215 immunology - Abstract
Summary Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations were comprised of two subsets: FLT3- and IRF4-dependent CD24+CD64− DCs and contaminating CSF-1R-dependent CD24−CD64+ macrophages. Functionally, loss of CD24+CD11b+ DCs abrogated CD4+ T cell-mediated interleukin-17 (IL-17) production in steady state and after Aspergillus fumigatus challenge. Human CD1c+ DCs, the equivalent of murine CD24+CD11b+ DCs, also expressed IRF4, secreted IL-23, and promoted T helper 17 cell responses. Our data revealed heterogeneity in the mouse CD11b+ DC compartment and identifed mucosal tissues IRF4-expressing DCs specialized in instructing IL-17 responses in both mouse and human. The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies., Highlights • Mucosal CD11b+ DCs consist of CD24+CD64− DCs and CD24−CD64+ macrophages • Mucosal CD24+CD11b+ DCs are IRF4-dependent • IRF4-dependent CD24+CD11b+ DCs secrete IL-23α and control mucosal IL-17 responses • Human CD1c+CD11b+ DCs are functional homologs of murine CD24+CD11b+ DCs
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- 2012
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