1. Follicular B cell trafficking within the spleen actively restricts humoral immune responses.
- Author
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Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, and Sebzda E
- Subjects
- Animals, Antigens, CD19 genetics, Antigens, CD19 immunology, Antigens, T-Independent genetics, Antigens, T-Independent immunology, Bone Marrow immunology, Cell Differentiation, Cells, Cultured, Kruppel-Like Transcription Factors deficiency, Kruppel-Like Transcription Factors immunology, Mice, Mice, Knockout, Receptors, CCR immunology, B-Lymphocytes cytology, B-Lymphocytes immunology, Cell Movement, Immunity, Humoral, Spleen cytology, Spleen immunology
- Abstract
Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the ability to quickly respond to MZ-associated antigens and pathogens in a T cell-dependent manner. This work demonstrates that in wild-type animals, naive FO B cells are actively removed from the MZ, thus restricting their capacity to respond to blood-borne pathogens., (Copyright 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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