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Ecofriendly solution processed organic transistors were demonstrated on a biodegradable paper substrate for −5-V operation. Blend of solution processed organic semiconductor TIPS-pentacene and polystyr- ene (PS) polymer was utilized to form the active layer, along with a natural protein, i.e., gelatin as a primary gate dielectric, both of which offer eco-friendliness from proc- ess and material aspects. Fabricated organic transistors showed excellent transistor behavior for p-channel opera- tion with a maximum process transconductance value of 15 nF/ $\text{V}\cdot \text{s}$ leading to the mobility of 2.3 cm2/ $\text{V}\cdot \text{s}$ obtained from capacitance density derived at 1 kHz. The average threshold voltage of −0.7 V suitable for low-voltage opera- tion was achieved along with decent ON/OFF current ratio of $\sim 10^{{4}}$ . High electrical stability was demonstrated through repeatability of transfer characteristics and bias-stress measurements. Excellent environmental stability in normal ambient was observed up to seven weeks. These devices showed circuit applicability with decent switching in resis- tive load inverters and good sensitivity to ultraviolet (UV) light, making them a suitable candidate for exploration for multifunctional and disposable application.