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With the advances in nanotechnology, novel nanosensing technologies can play a pivotal role in today’s society. Plasmonic sensing has demonstrated unprecedented detection reliability and resolution in a very compact form factor. Traditional plasmonic sensors leverage biofunctionalized metallic grating structures whose frequency response in transmission or reflection changes according to the presence of targeted biomarkers. However, these sensing setups require bulky measurement equipment to couple light to and from sensors for excitation and detection. In parallel, for over a decade, the nanoscale electromagnetic communication community has been leveraging plasmonic structures to transmit information at the nanoscale efficiently. By combining the two realms, this paper proposes the concept of joint nanoscale communication and bio-sensing systems enabled by plasmonic sensing nanoantennas. Sensing nanonodes can communicate from nanonode to nanonode for intra-body networks and from nanonode to a wearable device which, by leveraging the edge, can process and transmit the sensing information to the cloud, resulting in accurate diagnosis and reduced load on the medical testing infrastructure. First, we model the changes in the frequency response of a biofunctionalized plasmonic nanoantenna when exposed to different biomarkers. Then, we propose a chirp-spread spectrum excitation and detection system to enable simultaneous communication and sensing at the nanoscale. We present a data-driven human tissue model for communication through human tissue. We also present numerical results to demonstrate the performance of the proposed system. [ABSTRACT FROM AUTHOR]