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Silicon single-photon avalanche diodes (SPADs) are nowadays a solid-state alternative to photomultiplier tubes (PMTs) in single-photon counting (SPC) and time-correlated single-photon counting (TCSPC) over the visible spectral range up to 1-mum wavelength. SPADs implemented in planar technology compatible with CMOS circuits offer typical advantages of microelectronic devices (small size, ruggedness, low voltage, low power, etc.). Furthermore, they have inherently higher photon detection efficiency, since they do not rely on electron emission in vacuum from a photocathode as do PMTs, but instead on the internal photoelectric effect. However, PMTs offer much wider sensitive area, which greatly simplifies the design of optical systems; they also attain remarkable performance at high counting rate, and offer picosecond timing resolution with microchannel plate models. In order to make SPAD detectors more competitive in a broader range of SPC and TCSPC applications, it is necessary to face several issues in the semiconductor device design and technology. Such issues will be discussed in the context of the two possible approaches to such a challenge: employing a standard industrial high-voltage CMOS technology or developing a dedicated CMOS-compatible technology. Advances recently attained in the development of SPAD detectors will be outlined and discussed with reference to both single-element detectors and integrated detector arrays. [ABSTRACT FROM PUBLISHER]

Advanced fluorescence measurements on single molecules demand single-photon detectors with high-quantum detection efficiency, low noise, and high time resolution. We have developed a compact (82×60×30 mm) and versatile single-photon timing module (SPTM), based on a planar epitaxial single photon avalanche diodes (SPAD) working with a monolithic integrated active quenching and active reset circuit (i-AQC) and cooled by a Peltier element. The main operating parameters are computer controlled via RS-232 interface and the photon counting rate can be continuously monitored. The photon detection efficiency is 45% at 500 nm with cooling at -15°C, the dark counting rate is 5 c/s with SPAD operating at 5 V excess bias voltage, 10c/s operating at 10 V. The time resolution obtained with tightly focused illumination has 60-ps full-width at half-maximum. Comparative tests with the SPTM prototype and with an advanced commercially available photon counting module confirmed that the time resolution and sensitivity of the SPTM make it possible to resolve and measure even short lifetime components of a single molecule. The SPTM thus made possible experiments leading to a deeper insight into angstrom-scale structural changes of single-protein molecules. [ABSTRACT FROM PUBLISHER]