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Summary form only given. Experiments on the National Ignition Facility (NIF) have employed the first four beams to measure propagation and laser backscattering losses in large ignition-size plasmas. Gas-filled targets between 2 mm and 7 mm length have been heated from one side by overlapping the focal spots of the four beams from one quad operated at 351 nm with a total intensity of 2times1015 W cm-2. The targets were filled with 1 atm of CO2 producing of up to 7 mm long homogeneously heated plasmas with densities of ne = 5times1020 cm-3 and temperatures of Te = 2 keV. The high energy in a NIF quad of beams of 16 kJ, illuminating the target from one direction, creates unique conditions for the study of laser plasma interactions at scale lengths not previously accessible. The propagation through the large-scale plasma was measured with a gated X-ray imager that was filtered for 3.5 keV X-rays. These data indicate that the beams interact with the full length of this ignition-scale plasma during the last ~1 ns of the experiment when applying full laser beam smoothing consisting of phase plates, smoothing by spectral dispersion and polarization smoothing. Measurements that only apply phase plates show, laser beam filamentation and reduced propagation speed. These results demonstrate the NIF experimental capabilities and further provide a benchmark for three-dimensional modeling of the laser-plasma interactions at ignition-size scale lengths