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In the context of Enhanced Remote Area Communications (ERAC), Radio over Fiber (RoF) technology plays a crucial role in extending reliable connectivity to underserved and remote areas. This paper explores the significance of fifth-generation (5G) Digital Predistortion (DPD) role in mitigating non-linearities in Radio over Fiber (RoF) systems for enhancing communication capabilities in remote regions. The seamless integration of RoF and 5G technologies requires robust linearization techniques to ensure high-quality signal transmission. In this paper, we propose and exhibit the effectiveness of a machine learning (ML)-based DPD method for linearizing next-generation Analog Radio over Fiber (A-RoF) links within the 5G landscape. The study investigates the use of an optimized recurrent neural network (ORNN) based DPD experimentally on a multiband 5G new radio (NR) A-RoF system while maintaining low complexity. The ORNN model is evaluated using flexible-waveform signals at 2.14 GHz and 5G NR signals at 10 GHz transmitted over a 10 km fiber length. The proposed ORNN-based machine learning approach is optimized and is compared with conventional generalized memory polynomial (GMP) model and canonical piecewise linearization (CPWL) methods in terms of Adjacent Channel Power Ratio (ACPR), Error Vector Magnitude (EVM), and in terms of computation complexity including, storage, time and memory consumption. The findings demonstrate that the proposed ORNN model reduces EVM to below 2% as compared to 12% for non-compensated cases while ACPR is reduced by 18 dBc, meeting 3GPP limits.

Data generated from sources such as wearable sensors, medical imaging, personal health records, and public health organizations have resulted in a massive information increase in the medical sciences over the last decade. Advances in computational hardware, such as cloud computing, graphical processing units (GPUs), Field-programmable gate arrays (FPGAs) and tensor processing units (TPUs), provide the means to utilize these data. Consequently, an array of sophisticated Artificial Intelligence (AI) techniques have been devised to extract valuable insights from the extensive datasets in the healthcare industry. Here, we present an overview of recent progress in AI and biosensors in medical and life sciences. We discuss the role of machine learning in medical imaging, precision medicine, and biosensors for the Internet of Things (IoT). We review the latest advancements in wearable biosensing technologies. These innovative solutions employ AI to assist in monitoring of bodily electro-physiological and electro-chemical signals, as well as in disease diagnosis. These advancements exemplify the trend towards personalized medicine, delivering highly effective, cost-efficient, and precise point-of-care treatment.Furthermore, an overview of the advances in computing technologies, such as accelerated AI, edge computing, and federated learning for medical data, are also documented. Finally, we investigate challenges in data-driven AI approaches, the potential issues generated by biosensors and IoT-based healthcare, and the distribution shifts that occur among different data modalities, concluding with an overview of future prospects.