1. Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy
- Author
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Ivan Carlos Ferreira Antonello, Carlos Eduardo Poli-de-Figueiredo, Patrícia Barcelos Ogando, Breno José Acauan Filho, Bartira Ercília Pinheiro da Costa, and Matias C. Vieira
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Blood Pressure ,Gestational Age ,030204 cardiovascular system & hematology ,Nitric Oxide ,Nitric oxide ,Preeclampsia ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Nitrite ,Nitrites ,reproductive and urinary physiology ,NOx ,Creatinine ,Nitrates ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,female genital diseases and pregnancy complications ,Uric Acid ,Surgery ,Blood pressure ,Endocrinology ,chemistry ,Uric acid ,Female ,business - Abstract
Objectives: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. Methods: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. Results: Preeclampsia presented a significant increase in nitrate and NOx levels compared to the control group. Uric acid, gestational age, systolic and diastolic blood pressure, and creatinine showed correlation with nitrates and NOx. Conclusion: Increase of NO was observed in preeclampsia women. Failure in the mechanism of action, dependent on cyclic GMP, may justify this finding.
- Published
- 2016
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